Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...
Given k terminal pairs (s₁,t₁),(s₂,t₂),..., (s[subscript k],t[subscript k]) in an edge-weighted graph G, the k Shortest Vertex-Disjoint Paths problem is to find a collection P₁, P₂,..., P[subscript k] of vertex-disjoint paths with minimum total length, where P[subscript i] is an s[subscript i]-to-t[subscript i] path. As a special case of the...
3D datasets acquire great importance in the context of medical imaging. In this thesis we survey and enhance solutions to problems inherently associated with 3D datasets-processing time,noise and visualization. Efforts include development of a tool kit to provide a multi-threaded processing platform to cut processing time, produce real time visualization...
In this study, I investigate how target value uncertainty may lead to acquirer mispricing of an acquisition target and how the mispricing may be a determinant of goodwill impairment. To the extent the mispricing leads to both high and low industry-adjusted purchase price multiples (PPMs are my proxies for overpayment...
EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Popular applications such as P2P file sharing, multiplayer gaming, videoconferencing, etc. rely on the efficiency of content distribution from a single source to multiple receivers. Most users of these applications are on the widely prevalent source constraint networks such as the Digital Subscriber Line (DSL) and wireless networks. Overlay multicast...
Background: According to the National Mental Health Survey (NMHS), the treatment gap of any mental disorder in India among the general population was reported to be as high as 83% (R. S. Murthy, 2017). There is insufficient evidence currently describing the treatment gap among the child and adolescent population. Given...
BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Building intelligent computer assistants has been a long-cherished goal of AI. Many intelligent assistant systems were built and fine-tuned to specific application domains. In this work, we develop a general model of assistance that combines three powerful ideas: decision theory, hierarchical task models and probabilistic relational languages. We use the...
CTIP2, a novel C2H2 zinc finger protein, is a transcriptional repressor that functions by at least two mechanisms. CTIP2 interacts with and stimulates transcriptional repression mediated by COUP-TF family members. CTIP2 also represses transcription independently of COUP-TF proteins by direct, sequence-specific DNA binding activity. CTIP2 has been implicated in lymphoid...