Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
Improving crop cultivars for use on organic farms is pertinent, as current elite germplasm is less resilient within the more variable context of organic farm environments. Although a growing number of studies have focused on organic plant breeding in cereal crops, very few have focused on vegetable crops, especially those...
The draft genome of Streptomyces sp. strain ventii, an environmental isolate recovered from deep-sea hydrothermal vents in the Pacific Ocean, is presented along with the resequenced draft genomes of the type strains Streptomyces bohaiensis 11A07 and Streptomyces lonarensis NCL 716.
Secondary metabolites are synthesized by many microorganisms and provide a fitness benefit in the presence of competitors and predators. Secondary metabolism also can be costly, as it shunts energy and intermediates from primary metabolism. In Pseudomonas spp., secondary metabolism is controlled by the GacS-GacA global regulatory system. Intriguingly, spontaneous mutations...
Natural products (secondary metabolites) are small organic molecules derived
from plants, microbes, and marine organisms that have served as a diverse source of
useful compounds pharmaceuticals. New biologically active natural products are critical
as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce
diverse cytotoxic metabolites that represent potential...
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McPhail
Dr. Phil Proteau
Christopher Thornburg
Justyna Sikorska
OliverVining
Mariko
In the Pacific Northwest, regulatory agencies have recently
implemented management strategies for restoration and maintenance of wood
recruitment to streams over time. This allochthonous organic material is a
critical component in the geomorphic and biological structure of forested
streams. Mathematical models are commonly used to evaluate long-term
wood dynamics in...
This dissertation consists of four studies of Populus and Eucalyptus biotechnology and genomic science: 1) induction of floral sterility by tapetal expression of the ribonuclease Barnase in Populus; 2) CRISPR Cas9-mediated gene editing targeting LEAFY (LFY) and AGAMOUS (AG) homologs in Populus; 3) induction of floral sterility by CRISPR Cas9...
Stream systems in the Pacific Northwest have come to be understood in the absence of beaver (Castor canadensis). To understand the effect of beaver upon riparian plant communities, four basins in the lower Alsea drainage were examined to determine the effect of beaver and their impoundments on streamside herbaceous/shrub and...
Natural products (secondary metabolites) are small organic molecules derived
from plants, microbes, and marine organisms that have served as a diverse source of
useful compounds pharmaceuticals. New biologically active natural products are critical
as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce
diverse cytotoxic metabolites that represent potential...
Full Text:
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Mariko Nonogaki, Justyna Sikorska, and OliverVining for also assisting me with my
project, answering