The effect of vitamin B-6 (VB6) deficiency in mice on host
susceptibility to primary and secondary Moloney-sarcoma virus
(MSV)-induced tumor growth, cytotoxic activities of T cells,
antibodies and natural killer (NK) cells, and phagocytosis by
macrophages was examined. Five- to six-week old female C57B1/6 mice
were fed 20% casein diets...
Serine transhydroxymethylase (STHM), a pyridoxal 5'-
phosphate requiring enzyme is indirectly involved in
pyrimidine deoxynucleotide metabolism. A decrease in the
activity of this enzyme could lead to altered deoxycytidine
(dC) metabolism. This study was undertaken to determine if
a vitamin B-6 deficiency affects dC metabolism. The effect
of a vitamin...
The increasing knowledge of the significance of vitamin B₆ in
human metabolic processes has emphasized the importance of developing
reliable means of assessing nutritional status with respect to
this vitamin. One possible approach to this end is the measurement
of pyridoxal phosphate in blood or plasma, particularly since this
phosphorylated...
The bioavailability of vitamin B₆ in four selected foods
(bananas, filberts, soybeans and beef) was determined in five men,
aged 22 to 25 years, who were saturated with pyridoxine. The study
consisted of a five-day adjustment period followed by a 28-day experimental
period. All subjects consumed a constant diet containing...
The purposes of the research presented in this thesis were: (1)
to determine the precision with which it is possible to measure
changes in vitamin B6 compounds in the blood and urine following
oral doses of levels of vitamin B6 (as pyridoxine) which are in the
range of the normal...
Bioavailability (BA) of vitamin B6 (B-6) from foods may be
limited. The knowledge of the BA of B6 from food is important in
that this would help to understand if the B6 present in the diet of
individuals will meet the requirements for this vitamin.
The purpose of this study...
4-Pyridoxic acid is the major metabolite of all forms of
vitamin B₆ in mammalian species. The determination of 4-pyridoxic
acid, therefore, is important in the investigation of vitamin B₆
metabolism and for the establishment of human requirements for the
vitamin.
Although 4-pyridoxic acid is itself fluorescent, Huff and
Perlzweig (1944)...