A method for the control of absolute stereochemistry in
morphine syntheses has been demonstrated by the resolution
and efficient racemization of the advanced morphine precursor , 9-methoxy-3-methyl-5,6-dihydro-3H-benzofuro[3,2-e]isoquinoline-
7(7aH)-one, I. This was accomplished by the facile coversion of optically resolved I to its ring opened
form, 5,6,7,8-tetrahydro-10-methoxy-3-methyl-7-oxo[1]benzoxonino[
6,7-c]pyridinium tosylate, II, (Equation...
Developmental research has suggested that parenting practices may impact the
development of risk behaviors later in life. However, little evidence exists regarding
how parenting may impact actual decision processes that precede poor choices. This
study examined how parenting practices in early childhood influence the development
of decision-making competence (DMC), a...
Ocean acidification disrupts marine and coastal ecosystems’ carbonate chemistry, directly and indirectly affecting communities that depend on critical marine organisms. Ocean acidification research typically seeks to understand natural system responses; yet there is insufficient research that examines community and institutional responses or, more generally, their vulnerability to ocean acidification. This...
In this work, we systematically explore the effectiveness of optical aberration correction over a wide range of optical depths using the Segmented and Zernike Polynomial bases. We manufacture a set of 16 optical phantom samples consisting of a clear polyester resin substrate embedded with varying concentrations of aluminum oxide (Al₂O₃)...
The Seeds of Success (SOS) is a wildland seed collection program in support of the interagency Native Plant Materials Development Program (NPMP) and in partnership with the global conservation initiative, the Millennium Seed Bank Project of the Royal Botanic Gardens, Kew. SOS collections follow a set protocol with consideration for...
Hazelnuts are commonly consumed raw and are valued for their numerous health benefits and antioxidant properties. Increased foodborne illness outbreaks associated with Salmonella and Escherichia coli O157:H7 contamination of tree nuts and peanuts generate a need for improving agricultural sanitation procedures. Food-safe chemical sanitizers have shown promise for reducing pathogenic...
Described herein is the synthesis of an uncharged stereoregular oligonucleotide
analog consisting of cytosine bases linked at specific intervals to a polyamide backbone
derived from (L)-glutamic acid. Preparation of this analog entailed borane reduction of
(L)- pyroglutamic acid to give optically pure lactam alcohol 9. Tosylation and alkylation
with cytosine...