Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
Menstrual dysfunction (MD), possibly due to lower energy availability (EA), is prevalent in active women and associated with unfavorable heath consequences. PURPOSE: To determine if EA improvements in endurance-trained women, using a daily Carbohydrate-Protein supplement (CHO-PRO), will restore menstrual function and improve musculoskeletal health. METHODS: Athletes with MD (ExMD; n=8;...
Although female athletes are at greater risk of non-contact knee injuries than men, the factors that contribute to these injuries are not well understood. One important question is whether intense exercise influences the risk of knee injury, both acutely
and over the following days. The purpose of this study was...
Despite years of research, females continue to have a higher incidence of non-contact ACL injuries. One of the major findings of this research is that males and females perform certain tasks, such as, cutting, landing, and single-leg squatting, differently. In particular, females tend to move the knee into a more...
The purpose of this study was to examine the evidence of construct validity for self-report with assistance from a secondary source as a measure of physical activity (PA) in adults with intellectual disabilities (ID) in free-living environments. Thirty-seven participants (21 females, 16 males) with mild to moderate ID aged 19-74...
Running economy (RE) is the amount of oxygen utilized (ml.kg⁻¹min⁻¹) when
running a fixed speed, and it has been demonstrated to be an important factor
determining race performance in distance runners. There is evidence that running
economy and/or maximal oxygen consumption (VO₂max) improves over the course
of a training season...
Introduction: A bone deficit is found to persist five years following a hip fracture and 10 years post tibial fracture in adults. We examined the effect of whole body vibration (Vib) as a means for enhancing whole body composition and bone recovery following hindlimb unloading (HU) of adult female rats....
The major purpose of this research was to characterize partially degraded proteins
appearing in the ocular lens during aging and cataract, and to identify the responsible
proteolytic activities. This research is significant, because increased protein
degradation is associated with lens opacification and cataract. Determining the sites
where lens proteins become...
A backward fall is a major cause of hip fractures. Hip fractures have the potential to increase the mortality rate of older adults. Thus, the prevention of backward falls by older adults is a critical subject to be studied. Specifically, it remains unknown what effect aging-related losses in muscle strength...
It has been previously suggested that the walking pattern of individuals with Down syndrome is inefficient. This is thought to result from increased instability, particularly in the medio-lateral direction, due to the characteristic joint laxity and muscle hypotonia of individuals with DS. Therefore, this work was an attempt to gain...