This investigation is concerned with the determination of the temperature-effective period (T.E.P.) for crossvein development at physiological temperatures using three isogenic crossveinlesslike (cvl) lines of Drosophila melanogaster.
The method used to determine T.E.P. relies on temperature differences in phenotypes and on a program of transfers from one temperature to another...
The effect of X-irradiation on DNA synthesis in larval salivary
glands of Drosophila hydei was studied using the technique of liquid
scintillation spectrometry and autoradiography. DNA synthesis in
salivary glands of synchronized larvae was measured at successive
stages of third instar development by in vitro uptake of ³H-thymidine
for a...
Two identical single-ascending-dose studies evaluated the safety and pharmacokinetics (PK) of AVI-6002 and AVI-6003, two experimental combinations of phosphorodiamidate morpholino oligomers with positive charges (PMOplus) that target viral mRNA encoding Ebola virus and Marburg virus proteins, respectively. Both AVI-6002 and AVI-6003 were found to suppress disease in virus-infected nonhuman primates...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...