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Establishing a Humanized Microbiota Mouse Model of CVID-Enteropathy

Creator:

You, Hyekyoung Hannah

Abstract:

Common variable immunodeficiency (CVID) is the most common primary immunodeficiency that is characterized by low immunoglobulin levels in the body. CVID is indicated by failure of b cell differentiation and decrease production of immunoglobulins such as IgG and at least one of IgA or IgM. CVID patients with enteropathy (E-CVID)...

Resource Type:

Masters Thesis

Full Text:

AN ABSTRACT OF THE THESIS OF Hyekyoung Hannah You
Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:

You, Hyekyoung Hannah

Abstract:

Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...

Resource Type:

Honors College Thesis

Full Text:

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1) by Hyekyoung Hannah You
LncRNA regulation in mouse lung tumor from dibenzo[def,p]chrysene induced carcinogenesis in a transplacental Nrf2 knockout mouse model

Creator:

Patel, Karan, You, Hyekyoung, Siddens, Lisbeth, and Williams, David

Abstract:

Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....

Resource Type:

Poster

Full Text:

gene expression. 1Karan Patel, 1Hyekyoung (Hannah) You, 1,3 Lisbeth Siddens, 1,2,3David Williams 1