Effective treatment of larval bacterial diseases is a difficult problem when
culturing ornamental fish. Oral administration of antibiotics using existing
microparticle types is not effective due to high leakage rates; furthermore, injection of
larvae is not practical. Treatment is currently limited to use of antibiotic baths, . In this
study,...
The microsporidian parasite, Pseudoloma neurophilia, is the most commonly diagnosed infectious disease in laboratory populations of the zebrafish, Danio rerio. Infections by P. neurophilia are generally subclinical, however, they can become acute either incidentally or due to experimental immune suppression. Non-protocol induced variation can confound results in laboratory experiments using...
Zebrafish (Danio rerio) have become an increasingly important model organism for cancer research. There are several cancer models in which neoplasms are induced chemically or genetically. However, spontaneous (unknown etiology) neoplasms are rather common in zebrafish, particularly in older fish. For over a decade, spontaneous intestinal neoplasia and preneoplastic intestinal...
Mycobacteriosis is a common disease of laboratory zebrafish (Danio rerio). Different infection patterns occur in zebrafish depending on mycobacterial species. Mycobacterium marinum and M. haemophilum produce virulent infections associated with high mortality, whereas M. chelonae is more wide spread and not associated with high mortality. Identification of mycobacterial infections to...
The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...