Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Fluorinated chemicals (FCs) have been used since the 1950s in many industrial and commercial applications because of their unique properties such as chemical inertness, resistance to heat and their ability to repel water and oils. Concerns regarding potential environmental or human health risk from FCs exposure have emerged due to...
Cell culture systems have provided many insights into
eukaryotic gene expression and other biochemical
mechanisms. Since the cell represents the smallest living
unit of any organism it provides a desirable in vitro
system, allowing biochemical studies without the complex
physiology of an entire animal. However, processes
involving intracellular mechanisms, such...
Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
microRNAs (miRNAs), ~21-24 nucleotide-long RNAs that post-transcriptionally regulate gene expression, have rapidly become one of the most extensively studied mechanisms of the past decade. Since their discovery as temporal regulators of post-embryonic development in C. elegans, miRNAs have been functionally implicated in almost every cellular process investigated to date. miRNAs...
There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...