In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...
The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of
senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted
melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and
ribonucleotide...
Accurate estimation of historical abundance provides an essential baseline for judging the recovery of the great whales. This is particularly challenging for whales hunted prior to twentieth century modern whaling, as population-level catch records are often incomplete. Assessments of whale recovery using pre-modern exploitation indices are therefore rare, despite the...
Sea surface temperatures (SST) and inorganic continental input over the last 25,000 years (25 ka) are reconstructed in the far eastern equatorial Pacific (EEP) based on three cores stretching from the equatorial front (~0.01°N, ME0005-24JC) into the cold tongue region (~3.6°S; TR163-31P and V19-30). We revisit previously published alkenone-derived SST...
Since the decimation of the southern right
whale Eubalaena australis population in New Zealand by
whaling, research on its recovery has focused on the wintering
ground at the Auckland Islands, neglecting potentially
important wintering habitat at Campbell Island. For
the first time in 20 years we conducted an expedition to...
Background: Medication complexity is a large determinant of adherence. Few studies have explored the relationship between cognitive impairment and medication complexity.
Objective: To evaluate whether cognitive impairment is associated with medication complexity for prescription and over-the-counter (OTC) medications.
Methods: In this cross-sectional analysis, we studied the association between cognitive impairment...