Quinolinate (QUIN) is an endogenous neurotoxic product of the kynurenine
pathway of tryptophan metabolism. Quinolinate is a selective agonist of the NMDA
family of glutamate receptors and, as such, may play a role in the pathology of a number
of major central nervous system (CNS) disorders. These include both chronic...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
Powder injection molding (PIM) is a net fabrication technique that combines the
complex shape-forming ability of plastic injection molding, the precision of die-casting,
and the material selection flexibility of powder metallurgy. For this
study, the design issues related to PIM for fabrication of thin-walled high-aspect
ratio geometries were investigated. These...