Article
 

ChristensenJohnPharmacyCalciumChlorideNeonatal_DataS1.xls

Public Deposited

Contenu téléchargeable

Télécharger un fichier
https://ir.library.oregonstate.edu/concern/articles/qv33rz496

Descriptions

Attribute NameValues
Creator
Abstract
  • INTRODUCTION: We have previously reported results of precipitation studies for neonatal parenteral nutrition solutions containing calcium chloride and sodium phosphate using visual methods to determine compatibility. The purpose of this study was to do further testing of compatibility for solutions containing calcium chloride using more sensitive methods. METHODS: Solutions of Trophamine (Braun Medical Inc, Irvine, CA) and Premasol (Baxter Pharmaceuticals, Deerfield, IL) were compounded with calcium chloride and potassium phosphate. Controls contained no calcium or phosphate. After incubation at 37° for 24 hours solutions without visual precipitation were analyzed to determine mean particle size using dynamic light scattering from a laser light source. RESULTS: Particle sizes were similar for control solutions and those without visual precipitation and a mean particle size <1000 nm. Compatible solutions were defined as those with added calcium and phosphate with no visual evidence of precipitation and mean particle size <1000 nm. In solutions containing 2.5–3% amino acids and 10 mmol/L of calcium chloride the maximum amount of potassium phosphate that was compatible was 7.5 mmol/L. CONCLUSION: Maximum amounts of phosphate that could be added to parenteral nutrition solutions containing Trophamine and calcium chloride were about 7.5–10 mmol/L less for a given concentration of calcium based upon laser methodology compared to visual techniques to determine compatibility. There were minor differences in compatibility when adding calcium chloride and potassium phosphate to Premasol versus Trophamine.
Déclaration de droits

Des relations

Parents:

Articles

La vignette Titre Date de téléchargement Visibilité actes
file details ChristensenJohnPharmacyCalciumChlorideNeonatal_DataS1.xls 2017-07-26 Public Télécharger