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Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformations in F1 offspring

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  • Perfluorooctanesulphonicacid (PFOS) is an organic contaminant that is ubiquitous in the environment, wildlife, and humans. Few studies have assessed the effects of chronic PFOS exposure on central nervous system function in aquatic organisms. The present study defined the behavioral effects of varying life span chronic exposures to low dose PFOS in zebrafish. The zebrafish were treated with vehicle control or 0.5μM PFOS during 1-21, 21-120, or 1-120 day post fertilization (dpf). Chronic PFOS exposure impaired the adult zebrafish behavior mode under the tapping stimulus. The movement speed of 1-120 dpf exposed fish was significantly increased compared with control, while 1-21 and 21-120 dpf exposed groups were not severely affected. PFOS residues in F1 embryos derived from parental exposure during both the 1-120 and 21-120 dpf groups was significantly higher than control, and F1 embryos in these two groups showed obvious malformations, such as uninflated swim bladder (USB) and bent spine (BS). Larvae of the parental exposed to PFOS from 1-21 or 21-120 dpf elicited a higher swim rate than control in both the light and dark periods. Embryos derived from the 1-120 dpf group showed a statistically lower speed in the light period and a higher speed in the dark period as compared with control. Though there is little PFOS residue in 1-21 dpf group, the adverse behavioral effects on both adult and F1 larvae indicate that exposure during the first 21 dpf induce long-term neurobehavior toxicity. Our findings demonstrate that chronic exposure to low dose PFOS in different life stage adversely impacts adult behavior, subsequent offspring malformation, and larval behavior.
  • This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Society of Environmental Toxicology and Chemistry and can be found at: http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291552-8618.,Additional authors (Liu, Xiaojuan and Zhu, Guonian) appear and the author order is revised on the published version of this article.
  • Keywords: perfluorooctanesulfonic acid, zebrafish embryo, chronic exposure, behavior
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  • Chen, J., Das, S. R., La Du, J., Corvi, M. M., Bai, C., Chen, Y., ... & Huang, C. (2013). Chronic PFOS exposures induce life stage–specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring. Environmental Toxicology and Chemistry, 32(1), 201-206. doi:10.1002/etc.2031
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  • 32
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  • 1
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  • This work was supported in part by funding from National Environmental Protection Public Welfare Science and Technology Research Program of China (No.200909089), the Research Program of Department of Education of Zhejiang Province (Y201010056), the International Collaboration Project from Wenzhou City Government (No.H20100062), the Natural Science Foundation of Zhejiang Province (Y2110659), and the National Institute of Environmental Health Sciences Grant #P30 ES000210.
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