Graduate Thesis Or Dissertation
 

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Público Deposited

Contenido Descargable

Descargar PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/0z709302c

Descriptions

Attribute NameValues
Creator
Abstract
  • Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and commercial forests. As part of a broad survey of secondary metabolites produced by plant-associated fungi, the research presented includes three fungi from terrestrial and marine sources that were assessed for their chemical diversity. Chemical analysis let to the isolation of a new metabolite from Zasmidium pseudotsugae, an epiphytic fungus closely associated with Douglas-fir trees. From Penicillium crustosum, an algal-derived fungal endophyte, known metabolites were isolated and subjected to antimicrobial screening. Lastly, eight isolates of the wheat pathogen Fusarium graminearum exhibiting different in planta pathogenicity were subjected to comparative, metabolomic analysis. In each instance presented, fungi produced different molecules that can be used as tools to understand the chemical ecology of fungi.
License
Resource Type
Fecha de Emisión
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Declaración de derechos
Publisher
Peer Reviewed
Language
Embargo reason
  • Pending Publication
Embargo date range
  • 2019-07-23 to 2020-08-24

Relaciones

Parents:

This work has no parents.

En Collection:

Elementos

Miniatura Título Fecha de subida Visibilidad Acciones
file details Gonzalez-MontielGiselaAbigail2021.pdf 2019-07-23 Público Descargar