Cardiac calcification and lipid changes in the cotton rat (Sigmodon hispidus texianus) Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/9306t166s

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  • The purpose of this thesis was (1) to determine a dietary regimen which would produce the greatest incidence of cardiac calcification in the cotton rat and (2) to determine the fatty acid composition of heart tissue. Maximum incidence of cardiac calcification occurred from feeding torula yeast ration supplemented with 0.5% sulfate as either the sodium or potassium salt. Calcium and magnesium sulfate salts had aprotective effect. Both 0.25 and 1.0% sulfate (potassium salt) increased the incidence somewhat. Neither selenium (0.1 ppm) nor vitamin E (60 mg/kg) gave complete protection to the cotton rat from the sulfate effect. Linolenic acid deficiency enhanced the condition which was partially protected by linolenic acid supplementation. Sulfate nullified the effects of linolenic acid. Neither inositol (0.1%) no methionine (0.5%) had any marked effect on the myopathy. There was no significant difference in the lipid composition between normal and calcified cardiac tissue. Changes in the fatty acid composition were found as a function of the feeding regimen and were independent of the myopathy. Supplemented sulfate reduced the level of 18:1 and the di-valent sulfate salts markedly increased the level of 18:0 more than did the mono-valent salts as compared to the basal regimen. Other dietary regimens did not markedly alter the fatty acid composition of the cardiac tissue.
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