Graduate Thesis Or Dissertation
 

Effect of oral contraceptives in women on the plasma and urinary levels of vitamin B₆

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  • The effect of oral contraceptives on urinary and plasma vitamin B₆ as well as erythrocyte transaminase activities was investigated in women. Five women who were taking oral contraceptives and four who were not using these drugs served as subjects. They were apparently healthy and free from any known metabolic disorder. The subjects, who consumed normal diets, recorded their dietary intake for three days. Twenty-four hour urine specimens were collected on two consecutive days by the subjects. On the morning of the second day blood for the various biochemical measurements was drawn from fasting subjects. Following the blood drawing the women were given an oral dose of 3 g of L-methionine. Results of the methionine load test are reported elsewhere. The subjects consumed diets that supplied at least two-thirds or more of their National Academy of Science-National Research Council (1974) Recommended Dietary Allowances (RDA) for most nutrients except iron and vitamin B₆. The mean dietary intake of vitamin B₆ was 1.57 mg per day for the untreated women and 1.52 for the oral contraceptive users. On both days the mean levels of free and total vitamin B₆ in urine were less in the oral contraceptive users than that in the untreated controls, but the differences were not statistically significant. There appeared to be some relationship between dietary intake of vitamin B₆ and urinary excretion of the vitamin. The methionine loading dose did not affect the excretion of vitamin B₆ The mean plasma level of vitamin B₆ was lower for the oral contraceptive users than for the untreated controls although the difference is not statistically significant. There was, however, a large variation in values among the subjects taking oral contraceptives. Two of them had extremely low plasma vitamin B₆ levels. Vitamin B₆ in the plasma did not appear to be related to dietary intake or urinary excretion of the vitamin. Erythrocyte glutamic oxaloacetic transaminase (EGOT) and erythrocyte glutamic pyruvic transaminase (EGPT) activities with and without in vitro stimulation with pyridoxal phosphate (PALPO) were also measured. There were no significant differences between the two groups in EGOT and EGPT activities with and without in vitro stimulation. According to the activity indexes (PALPO stimulated activity/activity without added PALPO) for EGOT and EGPT (Sauberlich et al., 1972), all subjects had adequate vitamin B₆ nutritional status. Activity indexes for EGOT and EGPT did not appear to be related to urinary or plasma levels of vitamin B₆ Urinary and plasma vitamin B₆ levels and erythrocyte trans- aminase activities were not related to the length of time the women had been taking oral contraceptives or the estrogen content of their oral contraceptive agent.
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