Graduate Thesis Or Dissertation
 

The comparative pharmacodynamics of three organophosphate pesticides on host rabbits and two ectoparasites

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/r494vn62r

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  • Proban, Famphur and Tiguvon were administered intravenously, subcutaneously, and orally at varying concentrations to 101 female rabbits. The cholinesterase (ChE) activity levels of both plasma and red blood cells were tested, as was tick and mosquito ChE, at various times before and after dosage. The determinations measured the inhibition of ChE due to pesticidal activity. Coxarelations between host blood ChE activity fluctuations and ectoparasite ChE activity were observed. Ectoparasite mortality commenced at 32% ectoparasite ChE activity depression and there was 100% mortality at 68% ChE activity depression, No mortality of ectoparasites was observed to occur between the 24 and 96 hour postdosage period. Mated female ticks that had been exposed to sublethal doses of pesticide laid no eggs. Residue studies indicated that Proban and Famphur were degraded rapidly and excreted in the urine and feces. Tiguvon was more persistent and remained in certain tissues for approximately 28 days. Therapeutic, subcutaneous dosages of all three pesticides eliminated ear mites from rabbits within 24 hours. Reduction in temperature was fatal to mosquitoes that had received sublethal doses of pesticide in their blood meal. Reproductive capabilities of rabbits were not impaired by therapeutic dosages of the pesticides.
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