Graduate Thesis Or Dissertation
 

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

公开 Deposited

可下载的内容

下载PDF文件
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/tq57nt19q

Descriptions

Attribute NameValues
Creator
Abstract
  • This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and showed that the controlled release properties of the multiple-layered coated beads were present but decreased upon compaction and crushing. Itraconazole solid formulations were formulated using solid dispersion and solvent/co-cosolvent techniques. Solid dispersion of itraconazole in polyethylene glycol 20000 (PEG 20000) with trisodium citrate gave higher rate of dissolution than dispersion in PEG 20000 alone but didn't have as much effect as desired on rate of drug dissolution. Neutralized acetic acid itraconazole loaded beads exhibited the same in vitro and in vivo release patterns as Sporanox®. Itraconazole liquid formulations were developed and evaluated. Polyethylene glycol 400 (PEG 400) and acetic acid mixtures were found to be a good cosolvent system to solubilize itraconazole and showed good physical stability. Acetic acid, citric acid, and tartaric acid were studied to minimize the amount of PEG 400 needed to produce 1% (w/v) itraconazole solution. Citric acid alone or combined with other agents produced a good physically stable solution; however, these solutions didn't have as much extent as desired on drug dissolution. Bioavailability and bioequivalence of itraconazole capsule was determined is 13 fasted human volunteers and compared to Sporanox®. The 90% confidence intervals for individual percent ratios of the Cmax, AUC₀₋₇₂ and AUC0-inf were above the range of 80 to 125%, suggesting that these formulations are not bioequivalent. However, this new formulation significantly increased amount of itraconazole absorbed and Cmax of itraconazole in plasma. A novel controlled release tablet which releases a drug independently of pH and paddle speed, following a lag time and with zero-order kinetics identically to an osmotic pump but using a matrix tablet coated with a diffusional barrier membrane was produced and evaluated. This new matrix tablet generates a diffusional barrier support platform on horizontal surfaces in situ and can be used as an alternative to other zero-order release systems.
License
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Non-Academic Affiliation
Subject
权利声明
Publisher
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome, 256 Grayscale, 24-bit Color) using Capture Perfect 3.0.82 on a Canon DR-9080C in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces

关联

Parents:

This work has no parents.

属于 Collection:

单件

缩略图 标题 上传日期 公开度 行动
file details RakkankaVipaporn2003.pdf 2017-08-03 公开 下载