Graduate Thesis Or Dissertation
 

The role of perinatal androgens in the development of neuroendocrine and behavioral characteristics of the gray-tailed vole, Microtus canicaudus

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/vt150m418

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  • These studies examined the role of perinatal androgen in the development of neuroendocrine and behavioral characteristics of gray-tailed voles, Microtus canicaudus. When mature, females exhibited alternating vaginal smear patterns or persistent vaginal cornification; estrogen and progesterone concentrations were not correlated with vaginal smear patterns. Corpora lutea were not observed in females showing a variety of vaginal smear patterns, nor were corpora lutea observed after administration of estrogen alone, or in combinataion with progesterone. These findings indicate that voles do not release cyclic ovulatory surges of luteinizing hormone. Ovariecetomized female voles implanted with testosterone displayed masculine copulatory behavior patterns virtually indistinguishable from those of normal males; These behavioral and endocrine characteristics of female voles are similar to those of other rodent females treated with testosterone during development. The hypothesis that female voles are androgenized by exposure to endogenous testosterone was supported by the finding that female voles have high concentrations of plasma testosterone during development. However, perinatal treatment with antiandrogens or antiaromatases did not affect vaginal smear patterns, ovulatory responses to estrogen and progesterone administration, or the behavioral response to testosterone after ovariectomy. Castrated male M. canicaudus did not display female-typical behaviors when treated with estrogen or estrogen plus progesterone in adulthood; perinatal androgen manipulations did not affect the potential for female receptive behaviors in males. Specifically, neither castration within 3 hours of birth nor perinatal treatment with antiandrogens or antiaromatases enhanced behavioral responses to estrogen in male voles. In addition, prolonged neonatal testosterone treatment did not decrease the potential for feminine behaviors in female voles. These findings suggest that the development of female receptive behaviors in voles requires more than the absence of perinatal androgen exposure. Female voles did not exhibit feminine behavioral responses to estrogen if ovariectomized prepubertally, suggesting that the development of female sexual behaviors may require prepubrertal exposure to ovarian secretions.
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