Investigations into the Mechanism of Action of Dengue Virus Inhibitor Compounds

Honors College Thesis

Público Deposited

Citeable URL: https://ir.library.oregonstate.edu/concern/honors_college_theses/000001804

Descriptions

Attribute Name	Values
Creator	Schneider, Christine A.
Abstract	Several compounds have been recently identified which are effective against dengue virus, a tropical arbovirus highly prevalent in southeast Asia and central America. Initial intrinsic fluorescence characterization of the mechanism of action of compound B reveals binding affinity to the dengue capsid protein. A molecular beacon unwinding assay and malachite green ATPase assay indicate that compound C works to disrupt a component of the RNA-dependant helicase ATPase activity, possibly by competitively inhibiting RNA binding. These results are preliminary and further study is warranted to fully characterize the action of all three compounds. Key Words: Dengue virus, antiviral, capsid, helicase, NS3
License	All rights reserved
Resource Type	Honors College Thesis
Fecha Disponible	2011-08-05T21:57:14+00:00
Fecha de Emisión	2011-05-26
Degree Level	Bachelor's
Degree Name	Honors Bachelor of Science (H.B.S.)
Degree Field	Biochemistry and Biophysics
Degree Grantor	Oregon State University
Commencement Year	2011
Advisor	Hruby, Dennis E.
Committee Member	Jordan, Robert
Non-Academic Affiliation	Oregon State University. Honors College
Declaración de derechos	In Copyright
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Replaces	http://hdl.handle.net/1957/22410

Parents:

This work has no parents.

En Collection:

Miniatura	Título	Fecha de subida	Visibilidad	Acciones
	Christine_Schneider_Thesis.pdf	2017-07-30	Público	Descargar