Index Catalog // ScholarsArchive@OSU

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Creator:: Yin, Ruichuan, Zhang, Dapeng, Song, Yuling, Zhu, Ben-Zhan, and Wang, Hailin
Abstract:: Polyhalogenated quinones are a class of carcinogenic intermediates. We found recently that the highly reactive and biologically/environmentally important center [dot]OH can be produced by polyhalogenated quinones and H₂O₂ independent of transition metal ions. However, it is not clear whether this unusual metal-independent center dot OH producing system can induce potent...
Resource Type:: Article
Full Text:: , China, 2Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Polyhalogenated

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Creator:: Sheng, Zhi-Guo and Zhu, Ben-Zhan
Abstract:: BACKGROUND: Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve...
Resource Type:: Article
Full Text:: , Beijing, People’s Republic of China; 2Linus Pauling Institute, Oregon State University, Corvallis, Oregon

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Creator:: Zhu, Ben-Zhan, Chao, Xi-Juan, Huang, Chun-Hua, and Li, Yan
Abstract:: The dipyridophenazine (dppz) based ruthenium polypyridyl complexes are known as molecular ‘light-switches’ for DNA. This property is poised to serve in diagnostic and therapeutic applications, but the poor cellular uptake restricts their use in live cells. Herein, we show that the cellular uptake, and more interestingly and surprisingly, the nuclear...
Resource Type:: Article

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:: Lytle, Kelli A. and Jump, Donald B.
Abstract:: Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Resource Type:: Article
Full Text:: Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, 2 Linus Pauling

HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

Creator:: Kang, Y., Nian, H., Rajendran, P., Kim, E., Dashwood, W. M., Pinto, J. T., Boardman, L. A., Thibodeau, S. N., Limburg, P. J., Löhr, C. V., Bisson, W. H., Williams, D. E., Ho, E., and Dashwood, R. H.
Abstract:: Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Resource Type:: Article

Phytochemicals in fruits of Hawaiian wild cranberry relatives

Creator:: Hummer, Kim, Durst, Robert, Zee, Francis, Atnip, Allison, and Giusti, M. Monica
Abstract:: BACKGROUND: Cranberries (Vaccinium macrocarpon Ait.) contain high levels of phytochemicals such as proanthocyanidins (PACs). These polymeric condensations of flavan-3-ol monomers are associated with health benefits. Our objective was to evaluate phytochemicals in fruit from Hawaiian cranberry relatives, V. reticulatum Sm. and V. calycinum Sm. Normal-phase HPLC coupled with fluorescence and...
Resource Type:: Article
Full Text:: 97333, USA b Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA c US

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice

Creator:: Jump, Donald B., Depner, Christopher M., Tripathy, Sasmita, and Lytle, Kelli A.
Abstract:: The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased in parallel with central obesity and is now the most common chronic liver disease in developed countries. NAFLD is defined as excessive accumulation of lipid in the liver, i.e., hepatosteatosis. The severity of NAFLD ranges from simple fatty liver (steatosis)...
Resource Type:: Article
Full Text:: Health Sciences Linus Pauling Institute Oregon State University Corvallis Oregon, 97331

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Creator:: Trias, Emiliano, Cassina, Patricia, Martínez-Palma, Laura, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis, Ibarburu, Sofía, Barreto-Núñez, Romina, Babdor, Joël, Maciel, Thiago T., Guillo, Matthias, Gros, Laurent, Dubreuil, Patrice, and Díaz-Amarilla, Pablo
Abstract:: Background: In the SOD1^G93A mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such aberrant glial cells will decrease motor neuron death and prolong...
Resource Type:: Article
Full Text:: , Uruguay. 12Linus Pauling Institute, Department of Biochemistry and Biophysics, Environmental Health

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Creator:: Conley, Melissa N., Wong, Carmen P., Duyck, Kyle M., Hord, Norman, Ho, Emily, and Sharpton, Thomas J.
Abstract:: Introduction. Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the...
Resource Type:: Article

Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials

Creator:: Angelo, Giana, Drake, Victoria J., and Frei, Balz
Abstract:: We reviewed recent scientific evidence regarding the effects of MVM [multivitamin/mineral] supplements on risk of chronic diseases, including cancer, cardiovascular disease, and age-related eye diseases. Data from both randomized controlled trials (RCTs) and observational, prospective cohort studies were examined. The majority of scientific studies investigating the use of MVM supplements...
Resource Type:: Article
Full Text:: trials Giana Angelo, PhD, Linus Pauling Institute; Victoria J. Drake, PhD, Linus Pauling

ScholarsArchive@OSU

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

Phytochemicals in fruits of Hawaiian wild cranberry relatives

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials

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