Background
Feline injection-site sarcoma (FISS) is a rare and aggressive tumor associated with vaccines, drug injections, and skin trauma in cats. The understanding of FISS remains limited, posing challenges in its diagnosis, treatment, and prevention. In this study, we analyzed the differential expression of miRNAs and their target genes in...
Wheat is an important part of a healthy and balanced diet, requiring six servings per day to maintain a recommended 2000 Calorie intake (McRae, 2017). Because of this more land than almost any other kind of cereal is set aside for the purposes of growing wheat. To keep up with...
Onion thrips (Thrips tabaci) are pests found in onion fields of the Treasure Valley, which is located in Eastern Oregon and Western Idaho. Thrips cause damage to this high value crop by feeding on the onion’s extracellular fluid, making photosynthesis more difficult to occur. The feeding from the thrips can...
There is a growing need to establish alternative approaches for assessing hazard from chemical exposure compared to the traditional method of animal testing. Approaches that relate chemical structure to biological activity are gaining acceptance in the field as in silico methods for characterizing and predicting chemical toxicity. In this study,...
Phytophthora ramorum is the causal agent of Sudden Oak Death (SOD), which is an economically and environmentally important disease causing up to 80% mortality of tanoaks in Pacific Northwest coastal forests (LeBoldus et al., 2022). There are currently four clonal lineages in the United States and Europe, named North America...
Sweetpotatoes are a highly nutritious staple crop, playing an important role in global nutritional security. Although the majority of research in the United States (U.S.) focuses on the cultivation of the storage roots, both the leaves and roots are edible. Sweetpotatoes are indigenous to the Andes Region of South America;...
Female dairy cattle are particularly prone to infertility/subfertility with pregnancy rates ranging as low as 27% to a high 40%. On average it takes more than one breeding/insemination event for dairy cattle to become pregnant. This results in a loss of the number of calves a female would have per...
Infertility is an issue affecting millions of women across the globe, yet the causes are not fully understood, and treatment options are often ineffective. The evaluation of reproductive hormones has been a common tool used by fertility clinics as a way to predict the ovarian response to treatment and gain...
To evaluate and monitor insecticide resistance in onion thrips Thrips tabaci on onion (Allium cepa), we conducted a study using three field populations in the Treasure Valley of eastern Oregon and southwestern Idaho using the insecticides Lannate (methomyl) and Exirel (cyantraniliprole). To evaluate these two insecticides, biological assays were conducted...
Polycyclic aromatic hydrocarbons (PAHs) are a known class of chemicals that are linked to a multitude of adverse health outcomes. There are over 1,500 of these chemicals across various families and subgroups. 16 of these PAHs, known as parent PAHs, are identified by the EPA for focused risk assessment within...
Pacific Northwest temperate rainforests are anticipated to experience increasingly frequent and severe wildfires in the foreseeable future due to climate change, increased fuel loads, and deforestation. Soil, underlying these forests, is the largest terrestrial carbon (“C”) reservoir. Fire disturbance influences soil C persistence, the timeframe and magnitude of which remain...
Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Volatile organic compounds (VOCs) play an integral role in climate change and as a carbon source for organisms living in a marine environment. These compounds have many sources, but the impacts of biogenically produced VOCs is not fully known. Phaeodactylum tricornutum was studied under axenic ideal growth conditions to determine...
Background: The immune response to microbial infections is compromised in beef cattle at parturition. Innate and adaptive immunoglobulin M (IgM) serve as initial antibodies during microbial infection before the generation of adaptive immunoglobulin G (IgG). Selenium (Se) is an essential micronutrient required by all mammals, which can improve immune responses...
BioResource Research thesis defense presentation for Tyler Sato Spofford.
The COVID-19 pandemic highlighted disparities in land access and food security. Research has shown that access to gardening reduces financial burdens on low-income households. Compared to homeowners, individuals and families in rental housing face added barriers to vegetable gardening and growing...
The COVID-19 pandemic highlighted disparities in land access and food security. Research has shown that access to gardening reduces financial burdens on low-income households. Compared to homeowners, individuals and families in rental housing face added barriers to vegetable gardening and growing food. These barriers include rental housing regulations and the...
Microplastics (<5mm) are a ubiquitous environmental pollutant that have the potential to cause significant harm in many fish species. Therefore, understanding the quantities at which they are being consumed by living organisms is crucial for characterizing risk. There are currently gaps in the microplastic literature regarding microplastic data from finfish...
Microplastics (<5mm) are a ubiquitous environmental pollutant that have the potential to cause significant harm in many fish species. Therefore, understanding the quantities at which they are being consumed by living organisms is crucial for characterizing risk. There are currently gaps in the microplastic literature regarding microplastic data from finfish...
Soil contains approximately 75% of the carbon pool on land - three times more than the amount stored in living plants and animals (Schlesinger 1999). Therefore, soils play a major role in maintaining a balanced global carbon cycle. Models of the soil carbon ecosystem assume a strong relationship between organic...
The decline of the Chinook Salmon has been a mystery of recent years due to their decline. It has been speculated that wild origin salmon have more vigor and survivability than hatchery reared fish. This is thought to be due to rearing conditions, possibly affecting sensory organ development. The sensory...
Background: Uterine inflammation (e.g., endometritis) causes negative economic effects in the beef industry by reducing reproductive performance. Current treatments for endometritis in beef cattle involve hormones and antibiotics, which can be expensive and are often ineffective. The endometrial immune response regulates the release of cytokines and chemokines in response to...
The decline of the Chinook Salmon has been a mystery of recent years due to their decline. It has been speculated that wild origin salmon have more vigor and survivability than hatchery reared fish. This is thought to be due to rearing conditions, possibly affecting sensory organ development. The sensory...
Hatcheries are used to produce salmon to augment the number of fish available for harvest, and to supplement wild populations that may be threatened with extinction. Although traditional hatchery rearing methods can produce many fish, they can pose risk to wild populations because they tend to produce salmon with lower...
Polycystic Ovary Syndrome (PCOS) is an idiopathic disorder prevalent in ~5-10% of reproductive-aged women. In PCOS women who become pregnant, many experience complications including increased susceptibility of having a miscarriage, high blood pressure, and gestational diabetes, among others. Additionally, exposure to PCOS may have transgenerational impacts: offspring may be at...
STEM education is delivered to K12 audiences by Pre-college Programs across the nation, many of which serve underrepresented and underserved students as part of their core missions. While there is robust attention to STEM curriculum development and college connection events in such programs, few have social-cultural aspects of learning as...
STEM education is delivered to K12 audiences by Pre-college Programs across the nation, many of which serve underrepresented and underserved students as part of their core missions. While there is robust attention to STEM curriculum development and college connection events in such programs, few have social-cultural aspects of learning as...
Hatcheries are used to produce salmon to augment the number of fish available for harvest, and to supplement wild populations that may be threatened with extinction. Although traditional hatchery rearing methods can produce many fish, they can pose risk to wild populations because they tend to produce salmon with lower...
Vitiligo is a disease characterized by depigmented patches of skin. The disease is known to involve the loss of melanocytes in the basal layer of the skin in affected areas, but the underlying mechanisms are unknown. Recent evidence suggests oxidative stress and disruptions to antioxidant pathways contribute to an autoimmune...
Anaerobic digestion is a common terminal step in wastewater treatment systems and produces valuable by-products such as biogas, a combination of carbon dioxide and methane. Biogas can be used to off-set energy costs, and along with the anaerobic co-digestion of fats, oils, and greases (FOG) has been found to increase...
The United Nations Food and Agriculture Organization (FAO) in the State of World Fisheries and Aquaculture 2018, has observed that the trend of the world’s marine fish stocks has been overexploited, depleted, and has exhibited decreasing trend within the fraction of biologically sustainable levels. While these situations are an alarming...
Top predators play important roles in regulating communities and ecosystem processes in freshwater ecosystems. In the headwater stream network, it is crucial to understand the interspecific interaction between multiple predators. In Oregon forested ecosystems, Coastal Giant Salamander (Dicamptodon tenebrosus) and cutthroat trout (Oncorhynchus clarkii) are the top predators in many...
Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...
Blueberry stem galls in Pacific Northwest are often attributed to Agrobacterium tumefaciens. The disease also is associated with indole-3-acetic-acid (IAA) producing bacteria, as described on cranberry stem gall. Lack of studies makes it difficult to conclude whether these two types of bacteria could be the causal agent of stem gall...
Air pollution and pollution patterns have become a hot topic over the last several years. Many studies have been launched due to the increasing concern with air quality. As urban areas grow, atmospheric heavy metal pollution grows proportionally. Reducing atmospheric heavy metal pollution, and consequent health issues, requires monitoring and...
The variability of heavy metal concentrations (Pb, Cd, Zn, and Cu) of the terrestrial moss Orthotrichum lyellii on single trees was evaluated at two sites in the Pacific Northwest, one relatively unpolluted and the other polluted. In addition, a reciprocal transplant of O. lyellii between the unpolluted and polluted sites...
Benzo[a]pyrene (B[a]P) is a common environmental pollutant produced from the incomplete combustion of organic matter, such as fossil fuel emissions. In vertebrates, B[a]P exposure is associated with hyperactivity, though the underlying mechanisms driving this effect are undescribed. Mounting evidence indicates that the gut microbiome, which is the diverse community of...
Succinate dehydrogenase (Sdh) inhibitor fungicides, such as boscalid, are effective for the management of gray mold caused by the fungal pathogen Botrytis cinerea. Unfortunately, resistance to boscalid was common among isolates of the pathogen from small fruits grown in Oregon. Boscalid-resistance is commonly associated with mutations in Sdh, especially in...
Biogas can be used to generate energy from a wide variety of sources. Wastewater treatment sludge is an effective source of waste to be used for generation of biogas to make energy which can be used to heat homes and run businesses. This would help decrease the use of fossil...
With over three billion pounds of berries grown nationally each year, strawberries are an important economic contributor to agriculture in the US (Grubinger, 2012). However the strawberry industry in Oregon has been in a period of transition over the past few years. Strawberry acreage, planted and harvested, as well as...
Oregon is the number three producer of strawberries in the nation despite the fact that Oregon strawberry acreage dropped from 2,600 acres in 2005 to 2,000 acres in 2014 (Beeles, 2015; NASS, 2019, Losh, 2017). With over three billion pounds of berries grown nationally each year, strawberries are an important...
Endophytes, foliage inhabiting fungi, are an unexplored source of fungal biodiversity and a potential resource for the production of bioactive natural products. In this research, leaf tissues from the species Arbutus menziesii, Rhododendron macrophyllum and the genus, Ilex and Salix were collected for the isolation of endophytic fungi. Fungal extracts...
Postpartum uterine inflammation (endometritis) is not uncommon in beef cattle, resulting in infertility and culling. Prolonged calving may contribute to the increased incidence of endometritis in heifers. Commonly used methods to treat endometritis in beef cattle include intrauterine antibiotics and/or hormone injections, which can result in meat residues. Platelet rich...
Bacterial endophytes have the potential to confer benefits to Douglas-fir (Pseudotsuga menziesii
), for instance drought tolerance. Bacterial endophytes originating from seeds are
especially important. This is because seed endophytes are more likely to be the first endophytes
to get established within the young host plant. The goals of...
Bacterial endophytes have the potential to confer benefits to Douglas-fir ( Pseudotsuga menziesii ), for instance drought tolerance. Bacterial endophytes originating from seeds are especially important. This is because seed endophytes are more likely to be the first endophytes to get established within the young host plant. The goals of...
Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health, particularly, anti-cancer properties. Certain Fagonia species contain various types of phytochemicals such as saponins, alkaloids, cardiac glycosides, flavonoids, terpenoids, and tannins. In this study, we investigated the phytochemical composition of a...
Energy production and consumption is a major environmental and economic concern in the world today. Biofuel produced from lignocellulosic biomass is being explored as an alternative energy source to petroleum. Lignocellulosic biomass is comprised of cellulose, hemicellulose, and lignin. To produce biofuels, lignocellulosic biomass must be broken down to expose...