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Filtering by: Subject Iron -- Absorption and adsorption Remove constraint Subject: Iron -- Absorption and adsorption Academic Affiliation Chemical, Biological and Environmental Engineering Remove constraint Academic Affiliation: Chemical, Biological and Environmental Engineering

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  • Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

    Creator:
    Ryder, Matthew P.
    Abstract:
    While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
    Resource Type:
    Masters Thesis
    Full Text:
    block. In this work, nisin adsorption at hydrophobic, silanized silica surfaces coated with F108, and

  • The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

    Creator:
    Alkhatib, Aveen K.
    Abstract:
    The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
    Resource Type:
    Masters Thesis
    Full Text:
    the biopharmaceutical industry to stabilize therapeutic proteins from aggregation and adsorption

  • The assessment of copper and zinc removal from highway stormwater runoff using Apatite II™

    Creator:
    Huang, Hsiao-Wen
    Abstract:
    Copper and zinc are heavy metals commonly present in highway stormwater runoff. Discharge of these metals to surface waters inhabited by sensitive aquatic species including threatened and endangered salmonids has necessitated the need for improved treatment techniques. Although copper is of the greater toxicological concern, zinc is often present at...
    Resource Type:
    Masters Thesis
    Full Text:
    zinc was likely due to a combination of processes including adsorption, ion exchange and

  • Quantifying nisin adsorption behavior at pendant polyethylene oxide brush layers

    Creator:
    Dill, Justen K.
    Abstract:
    A more quantitative understanding of peptide loading and release from polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. The antimicrobial peptide nisin shows potent activity against Gram-positive bacteria including the most prevalent implant-associated pathogens, its mechanism of action minimizes the...
    Resource Type:
    Masters Thesis
    Full Text:
    adsorption-elution experiments with nisin, at uncoated and PEO-coated surfaces. PEO layers were prepared by

  • Synthesis and evaluation of PEO-coated materials for microchannel-based hemodialysis

    Creator:
    Heintz, Keely
    Abstract:
    The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work, stable surface modifications with pendant polyethylene oxide (PEO) chains were produced on polycarbonate...
    Resource Type:
    Masters Thesis
    Full Text:
    microchannel and membrane materials. Protein adsorption was detected by measurement of surface-bound enzyme

  • Molecular origins of surfactant-mediated stabilization of protein

    Creator:
    Lee, Hyo Jin
    Abstract:
    Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
    Resource Type:
    Dissertation
    Full Text:
    and PS 80) will occur with surfactants that stabilize protein mainly by their own adsorption at

  • Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

    Creator:
    Auxier, Julie A.
    Abstract:
    Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
    Resource Type:
    Masters Thesis
    Full Text:
    uncoated surfaces following nisin, fibrinogen, and/or buffer challenges; and evaluation of adsorption and

  • Enhancement and modeling of cryogenic solid-state hydrogen storage systems with a novel microchannel thermal management device

    Creator:
    Loeb, Christopher S.
    Abstract:
    Compact storage systems demonstrating increased hydrogen storage capacity are the key to advancing the growth of the hydrogen economy throughout the world and reducing the global dependence on fossil fuels for transportation. The use of highly porous adsorbent materials for reversible hydrogen storage is a promising pathway towards achieving storage...
    Resource Type:
    Dissertation
    Full Text:
    is the enhancement of solid-state hydrogen adsorption systems through the development and inclusion

  • Method development for characterizing the hydrophobicity of engineered nanoparticles

    Creator:
    Lee, Fang Yu
    Abstract:
    Characterizing the hydrophobicity of nanoparticles can help us understand their fate and transport in the environment, as well as how nanoparticles may interact with biological systems. However, contact angle and partition coefficient have limitations in measuring the hydrophobicity of nanoparticles, thus promising methods to measuring the hydrophobicity of nanoparticles are...
    Resource Type:
    Masters Thesis
    Full Text:
    needed. Hydrophobic interaction chromatography (HIC) and dye adsorption were used to test the

  • Molecular origins of peptide entrapment in polyethylene oxide layers

    Creator:
    Wu, Xiangming
    Abstract:
    A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
    Resource Type:
    Dissertation
    Full Text:
    used to record the adsorption and conformational changes of (amphiphilic) WLBU2 and S-WLBU2, and