Search Constraints

Start Over
Filtering by: Creator Coops, Nicholas C. Remove constraint Creator: Coops, Nicholas C. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

Search Results

  • Synthetic studies of nonadrides

    Creator:
    Drapela, Nicholas Ernest
    Abstract:
    An asymmetric approach to the synthesis of byssochlamic acid (1) is described. Regioisomeric enzymatic differentiation is described in the selective hydrolysis of dimethyl ester 30 by porcine liver esterase. Chiral dimethyl ester 42 was prepared by desymmetrization of cyclopentene 34 using porcine liver esterase. A key intramolecular [2+2]cycloaddition-cycloreversion photometathesis of...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Nicholas E. Drape la for the degree of Doctor of Philosophy in Chemistry presented on August

  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Nicholas E

  • Addition of substituted phenylthiyl radicals to substituted α-methylstyrenes

    Creator:
    Geers, Brian Nicholas
    Resource Type:
    Masters Thesis
    Full Text:
    substituted α-methylstyrenes AN ABSTRACT OF THE THESIS OF BRIAN NICHOLAS GEERS for the degree of MASTER OF

  • Adsorption properties of virgin and irradiated graphite

    Creator:
    Spalaris, Constantine Nicholas
    Resource Type:
    Dissertation
    Full Text:
    ADSORPTION PROPERTIES OF VIRGIN AND IRRADIATED GRAPHITE by CONSTANTINE NICHOLAS SPALARIS A THESIS

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation
    Full Text:
    generation to quenching C. Kyle Almlie, Nicholas E. Larkey, and Sean M. Burrows Analytical Methods

  • The chemistry and device applications of amorphous thin-film interfaces

    Creator:
    Knutson, Christopher C.
    Abstract:
    Solid-state amorphous materials show amazing promise in thin-film electronics. The interface-to-bulk ratio of thin films makes interfacial chemistries of these systems of utmost importance. Thin films of amorphous metals, dielectrics and semiconductors have novel chemistries that are not only based upon their elemental constituent makeup, but also based upon the...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Christopher C. Knutson for the degree of Doctor of Pholosophy in

  • Hydrogen abstraction from 1-substituted adamantanes

    Creator:
    Owens, Peter Halliday
    Abstract:
    The relative rates of bridgehead hydrogen abstraction from a series of 1-substituted adamantanes by the trichloromethyl radical at 40.0°C. has been carried out. Utilizing the Hammett-Taft equation a p* value of -0.40 was obtained for this reaction. Application of the Kirkwood-Westheimer model for the transmission of substituent effects gave an...
    Resource Type:
    Masters Thesis
    Full Text:
    abstraction from a series of 1- substituted adamantanes by the trichloromethyl radical at 40.0 °C. has

  • Studies on the biosynthesis of the streptolidine moiety of streptothricin F

    Creator:
    Wityak, John
    Abstract:
    The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
    Resource Type:
    Dissertation
    Full Text:
    material generated 1 a labeled at C-4 and at C-3 of the streptolidine portion, fully in agreement with such

  • A study of the biosynthesis of sterols and related compounds by a bovine aorta preparation

    Creator:
    Walsh, Marilyn Ruth
    Abstract:
    Previous investigations of the biosynthesis of sterols by the arterial wall have shown that the intact aorta is capable of low level incorporation of labeled precursor into a sterol digitonide. The biosynthesis of sterols and related lipids by a cell-free preparation of bovine aorta was investigated in the present study....
    Resource Type:
    Masters Thesis
    Full Text:
    mevalonic acid -2 -C 14, the non- saponifiable fraction (NSF) of the incubation mixture was radioactive

  • Reaction Pathways of Oxo-Hydroxo Group 5 Clusters to Metal Oxide Thin Films

    Creator:
    Mansergh, Ryan H.
    Abstract:
    Oxo-hydroxo Group 5 metal clusters are an untapped resource to study and advance aqueous solution processing of metal oxide thin films. The tetramethylammonium (TMA) hexatantalate salt (TMA6[H2Ta6O19]) yields dense Ta2O5 films (~95% of the bulk ß-Ta2O5 density) with atomically smooth surfaces (<4 Å root mean square surface roughness). This same...
    Resource Type:
    Dissertation
    Full Text:
    produce amorphous tantalum oxide films at temperatures as low as 200 °C