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Filtering by: Creator Durgan, Christopher J. Remove constraint Creator: Durgan, Christopher J. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

    Creator:
    Ferreira, Andrew
    Abstract:
    The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Andrew J. Ferreira for the degree of Doctor of Philosophy in Chemistry

  • Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

    Creator:
    Salih, M. Quamar
    Abstract:
    Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
    Resource Type:
    Dissertation
    Full Text:
    ! Etherification! ! ! ! Abstract!approved:! ______________________________________________________! Christopher

  • The chemistry and device applications of amorphous thin-film interfaces

    Creator:
    Knutson, Christopher C.
    Abstract:
    Solid-state amorphous materials show amazing promise in thin-film electronics. The interface-to-bulk ratio of thin films makes interfacial chemistries of these systems of utmost importance. Thin films of amorphous metals, dielectrics and semiconductors have novel chemistries that are not only based upon their elemental constituent makeup, but also based upon the...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Christopher C. Knutson for the degree of Doctor of Pholosophy in

  • The development of aminal radicals for the synthesis of nitrogen-rich natural products

    Creator:
    Schiedler, David A.
    Abstract:
    Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: ______________________________________________________ Christopher M. Beaudry

  • Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

    Creator:
    Kim, GilSoo
    Abstract:
    The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Christopher M. Beaudry The first part of this manuscript is about the total synthesis of the

  • Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

    Creator:
    Vellucci, Jessica K.
    Abstract:
    Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Christopher M. Beaudry Aminal radical intermediates were generated by the method of

  • Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

    Creator:
    Ju, Xuan
    Abstract:
    Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Christopher M. Beaudry Dearomatization reactions exist broadly in biosynthesis and chemical

  • Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

    Creator:
    Emerson, Christopher R.
    Abstract:
    Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Christopher R Emerson for the degree of Doctor of Philosophy in

  • Asymmetric synthesis of cyclopropanes via a "zipper reaction"

    Creator:
    Lincoln, Christopher M.
    Abstract:
    The rearrangement of a homoallyl cation to a cyclopropylcarbinyl cation is thought to play a role in the biogenesis of a variety of cyclopropane-containing natural products,¹ a hypothesis which has previously led to the design of successful biomimetic syntheses of several natural products.² The strategy underlying this approach to cyclopropane...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Christopher M. Lincoln for

  • Electrochemical Advancement of Solid State Ion Selective Electrodes

    Creator:
    Bahro, Christopher
    Abstract:
    The general theme of this dissertation is the development of new analytical sensors to quantitatively study biological and environmental samples in aqueous and non-aqueous environments. A platinum ultramicroelectrode (UME) and a unique carbon-based pH microprobe were used to design a new SECM-based electrochemical bioassay. The Pt UME was used to...
    Resource Type:
    Dissertation
    Full Text:
    OF THE DISSERTATION OF Christopher Bahro for the degree of Doctor of Philosophy in Chemistry