Index Catalog // ScholarsArchive@OSU

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Creator:: DuBois, Barent Nathan
Abstract:: Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...
Resource Type:: Dissertation
Full Text:: during gestation and lactation, and all pups were weaned onto a rodent laboratory chow with access to

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Creator:: DuRoss, Allison N.
Abstract:: The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Resource Type:: Dissertation
Full Text:: nanoparticles, however, represent only a small class of nanomaterials that may be impactful in the field of

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Creator:: Newman, Nolan K.
Abstract:: The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Resource Type:: Dissertation
Full Text:: . Title: Development and Implementation of a Transkingdom Network Analysis Pipeline to Identify Drivers

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: Development and Testing of a Sustained Release Acetaminophen

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:: Carpenter, Evan L.
Abstract:: Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Resource Type:: Dissertation
Full Text:: ., keratinocytes). However, melanocytes encounter a large burden of oxidative stress during this process, due to

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:: Fernandes, Roberta P. M.
Abstract:: In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
Resource Type:: Dissertation
Full Text:: enzyme in the MEP pathway is 1-deoxy-D-xylulose 5- phosphate reductoisomerase (DXR). DXR is a promising

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Creator:: Zhang, Lingjuan
Abstract:: COUP-TFI, an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily, plays important roles in homeostasis and the CNS development, including differentiation, patterning, axonal projection, cell migration, cortical arealization and the temporal specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and the majority of...
Resource Type:: Dissertation
Full Text:: specification of neural stem cells. A number of COUP-interacting proteins have been described previously, and

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: horses. Pharmacokinetic study was conducted in a cross-over design in which the horses received co

Effects of Medicinal Herbs on Contraction Rate of Cultured Cardiomyocyte. Possible Mechanisms Involved in the Chronotropic Effects of Hawthorn and Berberine in Neonatal Murine Cardiomyocyte

Creator:: Salehi, Satin
Abstract:: Herbs have been used for many centuries in diverse civilizations for the treatment of heart disease. Only a few natural supplements claim to have direct cardiovascular actions including hawthorn (Crataegus spp.) and berberine derived from the Berberidaceae family. Several different studies indicate important cardiovascular effects of hawthorn and berberine. For...
Resource Type:: Dissertation
Full Text:: treatment of heart disease. Only a few natural supplements claim to have direct cardiovascular actions

ScholarsArchive@OSU

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Development and implementation of a transkingdom network analysis pipeline to identify drivers of disease

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Deciphering the molecular mechanisms of the transcriptional regulation mediated by orphan nuclear receptor COUP-TFI and C2H2 zinc finger protein Ctip2

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Effects of Medicinal Herbs on Contraction Rate of Cultured Cardiomyocyte. Possible Mechanisms Involved in the Chronotropic Effects of Hawthorn and Berberine in Neonatal Murine Cardiomyocyte

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