Index Catalog // ScholarsArchive@OSU

Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin

Creator:: Larkin, Andrew, Siddens, Lisbeth K., Krueger, Sharon K., Tilton, Susan C., Waters, Katrina M., Williams, David E., and Baird, William M.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are present in the environment as complex mixtures with components that have diverse carcinogenic potencies and mostly unknown interactive effects. Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family. To better understand and predict biological effects of...
Resource Type:: Article
Full Text:: . Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 54, 63–128. Fujii-Kuriyama, Y., Mimura, J., 2005

TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation—A 30-Year Odyssey

Creator:: Kerkvliet, Nancy I.
Abstract:: I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic Pathology Symposium “Toxicologic Pathology and the Immune System.” I had the opportunity to reminisce about events in the 1970s that set the stage for the birth and subsequent growth of the field of immunotoxicology and...
Resource Type:: Article
Full Text:: , and Y. Fujii-Kuriyama. 2009. Hypersensitivity of Aryl Hydrocarbon Receptor- Deficient Mice to

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: ; 12 Ramesh et al., 2004; Shimada and Fujii-Kuriyama, 2004). These DNA adducts, if not repaired

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Creator:: Koch, Daniel C.
Abstract:: The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....
Resource Type:: Dissertation
Full Text:: between the models (Lahvis and Bradfield 1998, Esser 2009). The Fujii- Kuriyama group generated AhR

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: systems upon metabolic activation to chemically reactive species (Shimada and Fujii-Kuriyama, 2004

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Creator:: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Lohr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., and Williams, David E.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Resource Type:: Article
Full Text:: Metabol. Dispos. 29 (2001) 1176-1182. 29. T. Shimada, Y. Fujii-Kuriyama, Metabolic activation of

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

Creator:: Larkin, Andrew
Abstract:: In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
Resource Type:: Dissertation
Full Text:: hydrocarbon receptor (AhR) activation (Fujii-Kuriyama and Mimura, 2005; Lin et al., 2003). The AhR pathway

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation

ScholarsArchive@OSU

Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin

TCDD: An Environmental Immunotoxicant Reveals a Novel Pathway of Immunoregulation—A 30-Year Odyssey

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

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