Index Catalog // ScholarsArchive@OSU

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Creator:: Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J., Bisson, William H., Cheng, Qiang, D'Abronzo, Leandro, Dornetshuber-Fleiss, Rita, Gosh, Paramita M., Gonalez-Guzman, Michael J., Lee, Tae-Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratoviski, Edward, Rojanasakul, Yon, Romano, Maria Fiammetta, Romano, Simona, Sinha, Kumar Ranjeet, Yedjou, Clement, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Ryan, Elizabeth P., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Salem, Hosni K., Woodrick, Jordan, Scovassi, Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Lowe, Leroy, and Park, Hyun Ho
Abstract:: Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
Resource Type:: Article
Full Text:: , B. J., Cheng, Q., D’Abronzo, L., Dornetshuber-Fleiss, R., ... & Park, H. H. (2015). Disruptive

Assessing the Impacts of Size, Structure, and Surface Chemistry on the Toxicity of Two High Production Organic Nanomaterials using the Embryonic Zebrafish Model

Creator:: Meredith, Ailcea N.
Abstract:: The low risk and sustainable implementation of nanotechnology requires understanding how nanomaterial physicochemical properties influence their toxicity. Major drivers of toxicity need to be avoided while maximizing product efficacy so nanomaterials can be produced to best serve their applications and be of low risk when intentionally or unintentionally released into...
Resource Type:: Masters Thesis
Full Text:: and pharmacokinetics (Li and Huang 2008; Albanese, Tang et al. 2012; Murugan, Choonara et al. 2015

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Creator:: Wehmas, Leah C.
Abstract:: The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Resource Type:: Dissertation
Full Text:: ; Cheng et al., 2011; Hanley et al., 2008; Kang et al., 2008a; Nie et al., 2007). There are also many

Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

Creator:: Tilton, Fred Anthony, 1973-
Abstract:: Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and effluent additives. DTCs and their related compounds have historical and current relevance in clinical and experimental medicine. DTC developmental toxicity is well established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a mechanism of action involving, "the inhibition of...
Resource Type:: Dissertation
Full Text:: ; Cheng and Trombetta 2004; Chung etal. 2000; Corsini et al. 2005; Nobel etal. 1997; Tonkin et al. 2000

Size- and Oxidation-Dependent Toxicity of Graphene Oxide Nanomaterials in Embryonic Zebrafish

Creator:: Lopez, Ryan
Abstract:: Graphene and its derivatives are two-dimensional hexagonal lattices that possess desirable physicochemical properties leading to an ever-expanding list of industrial and biomedical uses. Graphene oxides (GOs) are becoming a popular graphene alternative and while there have been human safety studies, investigations of developmental toxicity are lacking. The use of distinct...
Resource Type:: Masters Thesis
Full Text:: in other applications due to their distinct characteristics (Pei & Cheng, 2012). rGOs can be used

Per- and Polyfluoroalkyl Substances (PFAS): Protein Binding and Partitioning and Sorption in Light Non-Aqueous Phase Liquids

Creator:: Christie, Emerson C.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are anthropogenic surfactants that have recently been identified as persistent organic pollutants. These so called “Forever Chemicals” have been detected in drinking waters, ground waters, soils, and consumer and industrial products globally; with environmental impacts stretching into the artic, far from known PFAS sources. The...
Resource Type:: Dissertation
Full Text:: write-up and edits. Weixiao Cheng performed molecular modeling and contributed to manuscript write-up

Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

Creator:: Bisson, William H.
Abstract:: More needs to be done by the private sector to optimize the drug discovery and development pipeline. In addition, significant efforts should also be focused on the understanding of mechanism of diseases, on the characterization of unexplored biochemical pathways and on the validation of new protein targets. Chemical genomics, which...
Resource Type:: Article
Full Text:: of this encyclopedia was supported by the government (the Ming Dynasty) and Shizhen Li is the major

Continuous monitoring and modeling to assess pesticide exposure in critical habitat for Pacific salmonids

Creator:: Janney, Philip K.
Abstract:: Pacific Northwest and California freshwater resources are key elements in the life history and ecology of Pacific salmon and steelhead listed as threatened or endangered under the Endangered Species Act. Risk to listed Pacific salmonid species can be assessed by evaluating the spatial and temporal co-occurrence of salmonid species at...
Resource Type:: Dissertation
Full Text:: , animal health, and agricultural production (Cheng 1990, Costa 2008). Beginning in the 1940s

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Creator:: Smith-Roe, Stephanie L.
Abstract:: The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
Resource Type:: Dissertation
Full Text:: epoxide (B[c]PDE) (Duckett et al., 1996; Larson et al., 2003; Li et al., 1996; Mu et al., 1997; Wang et

Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced 𝛽-Cell Damage and Streptozotocin-Induced Diabetes

Creator:: Sharma, Bhesh Raj and Rhyu, Dong Young
Abstract:: This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by the Hindawi Publishing Corporation. The published article can be found at: http://dx.doi.org/10.1155/2015/169256
Resource Type:: Article
Full Text:: ,TheEndocrine System Pharmacology, Longman Group Ltd., London, UK, 2nd edition, 1991. [7] D. Cheng, B. Liang

ScholarsArchive@OSU

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Assessing the Impacts of Size, Structure, and Surface Chemistry on the Toxicity of Two High Production Organic Nanomaterials using the Embryonic Zebrafish Model

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

Size- and Oxidation-Dependent Toxicity of Graphene Oxide Nanomaterials in Embryonic Zebrafish

Per- and Polyfluoroalkyl Substances (PFAS): Protein Binding and Partitioning and Sorption in Light Non-Aqueous Phase Liquids

Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

Continuous monitoring and modeling to assess pesticide exposure in critical habitat for Pacific salmonids

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced 𝛽-Cell Damage and Streptozotocin-Induced Diabetes

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