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Analysis of the genome of leporid herpesvirus 4

Creator:

Babra, Bobby, Watson, Gregory, Xu, Wayne, Jeffrey, Brendan, Xu, Jia-Rong, Rockey, Dan, Rohrmann, George, and Jin, Ling

Abstract:

The genome of a herpesvirus highly pathogenic to rabbits, leporid herpesvirus 4 (LHV-4), was analyzed using high-throughput DNA sequencing technology and primer walking. The assembled DNA sequences were further verified by restriction endonuclease digestion and Southern blot analyses. The total length of the LHV-4 genome was determined to be about...

Resource Type:

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stands for the bootstrap value of 100. For details see Materials and Methods. 437 438 Supplemental
Sequence and comparative analysis of the genome of HSV-1 strain McKrae

Creator:

Watson, G., Xu, W., Reed, A., Babra, B., Putman, T., Wick, E., Wechsler, S., Rohrmann, G. F., and Jin, L.

Abstract:

Ocular infection by HSV-1 strain McKrae is neurovirulent in both mice and rabbits and causes fatal encephalitis in approximately 50% of animals. In addition, it spontaneously reactivates with high frequency relative to other HSV-1 strains in rabbits. We sequenced the McKrae strain genome and compared its coding protein sequences with...

Resource Type:

Article

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block of substitutions present in McKrae is adjacent to the nuclear localization signal (NLS) (amino