Index Catalog // ScholarsArchive@OSU

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Creator:: Rodriguez-Mari, Adriana, Wilson, Catherine, Titus, Tom A., Canestro, Cristian, BreMiller, Ruth A., Yan, Yi-Lin, Nanda, Indrajit, Johnston, Adam, Kanki, John P., Gray, Erin M., He, Xinjun, Spitsbergen, Jan, Schindler, Detlev, and Postlethwait, John H.
Abstract:: Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that...
Resource Type:: Article
Full Text:: pgen.1001357 1..20 Roles of brca2 (fancd1) in Oocyte Nuclear

Ultrastructural study of spontaneous orocutaneous papillomas of brown bullheads Ictalurus nebulosus

Creator:: Poulet, Frederique M. and Spitsbergen, Jan M.
Abstract:: Eight spontaneous orocutaneous papillomas of adult, wild-caught brown bullheads Ictalurus nebulosus and 4 anatomically matching control tissue samples were examined by electron microscopy. Ultrastructural characteristics of normal and neoplastic Malpighian epithelial cells were compared and neoplastic cells were described. Normal Malpighian epithelial cells of brown bullheads were similar to those...
Resource Type:: Article
Full Text:: similar to those of other teleosts. Euchromatic nucleus, abundant nuclear pores and numerous ribosomes

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Creator:: Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, del Pilar Lopez Pazmino, Maria, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, and Stainier, Didier Y. R.
Abstract:: Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-catenin. To...
Resource Type:: Article
Full Text:: ): e1005305. doi:10.1371/journal. pgen.1005305 Editor: Mary C. Mullins, University of Pennsylvania School of

Organelle trafficking of chimeric ribozymes and genetic manipulation of mitochondria

Creator:: Val, Romain, Wyszko, Eliza, Valentin, Clarisse, Szymanski, Maciej, Cosset, Anne, Alioua, Malek, Dreher, Theo W., Barciszewski, Jan, and Dietrich, Andre
Abstract:: With the expansion of the RNA world, antisense strategies have become widespread to manipulate nuclear gene expression but organelle genetic systems have remained aside. The present work opens the field to mitochondria. We demonstrate that customized RNAs expressed from a nuclear transgene and driven by a transfer RNA-like (tRNA-like) moiety...
Resource Type:: Article
Full Text:: With the expansion of the RNA world, antisense strategies have become widespread to manipulate nuclear

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...
Resource Type:: Article
Full Text:: of oncogenic krasV12 on liver development is shown in more detail in supplementary material Fig. S1

Analysis of the genome of leporid herpesvirus 4

Creator:: Babra, Bobby, Watson, Gregory, Xu, Wayne, Jeffrey, Brendan, Xu, Jia-Rong, Rockey, Dan, Rohrmann, George, and Jin, Ling
Abstract:: The genome of a herpesvirus highly pathogenic to rabbits, leporid herpesvirus 4 (LHV-4), was analyzed using high-throughput DNA sequencing technology and primer walking. The assembled DNA sequences were further verified by restriction endonuclease digestion and Southern blot analyses. The total length of the LHV-4 genome was determined to be about...
Resource Type:: Article
Full Text:: stands for the bootstrap value of 100. For details see Materials and Methods. 437 438 Supplemental

Sequence and comparative analysis of the genome of HSV-1 strain McKrae

Creator:: Watson, G., Xu, W., Reed, A., Babra, B., Putman, T., Wick, E., Wechsler, S., Rohrmann, G. F., and Jin, L.
Abstract:: Ocular infection by HSV-1 strain McKrae is neurovirulent in both mice and rabbits and causes fatal encephalitis in approximately 50% of animals. In addition, it spontaneously reactivates with high frequency relative to other HSV-1 strains in rabbits. We sequenced the McKrae strain genome and compared its coding protein sequences with...
Resource Type:: Article
Full Text:: block of substitutions present in McKrae is adjacent to the nuclear localization signal (NLS) (amino

Survey of Parasites In Threatened Stocks of Coho Salmon (Oncorhynchus kisutch) In Oregon By Examination of Wet Tissues and Histology

Creator:: Ferguson, Jayde A., St-Hilaire, Sophie, Peterson, Tracy S., Rodnick, Kenneth J., and Kent, Michael L.
Abstract:: We are conducting studies on the impacts of parasites on Oregon coastal coho salmon (Oncorhynchus kistuch). An essential first step is documenting the geographic distribution of infections, which may be accomplished by using different methods for parasite detection. Thus, the objectives of the current study were to (1) identify parasite...
Resource Type:: Article
Full Text:: and examination of wet material. Furthermore, we could not find any studies that have empirically

Apophallus microsoma N. SP. from Chicks Infected with Metacercariae from Coho Salmon (Oncorhynchus kisutch ) and Review of the Taxonomy and Pathology of the Genus Apophallus (Heterophyidae)

Creator:: Ferguson, Jayde A., Locke, Sean A., Font, William F., Steinauer, Michelle L., Marcogliese, David J., Cojocaru, Calin D., and Kent, Michael L.
Abstract:: Metacercariae of an unidentified species of Apophallus Luhe, 1909 are associated with overwinter mortality in coho salmon, Oncorhynchus kisutch (Walbaum, 1792), in the West Fork Smith River, Oregon. We infected chicks with these metacercariae in order to identify the species. The average size of adult worms was 197 x 57...
Resource Type:: Article
Full Text:: material of interest, we include here sequences from other heterophyids acquired by S.L., D.J.M., and C.C

Macroalgae Decrease Growth and Alter Microbial Community Structure of the Reef-Building Coral, Porites astreoides

Creator:: Thurber, Rebecca Vega, Burkepile, Deron E., Correa, Adrienne M. S., Thurber, Andrew R., Shantz, Andrew A., Welsh, Rory, Pritchard, Catharine, and Rosales, Stephanie
Abstract:: With the continued and unprecedented decline of coral reefs worldwide, evaluating the factors that contribute to coral demise is of critical importance. As coral cover declines, macroalgae are becoming more common on tropical reefs. Interactions between these macroalgae and corals may alter the coral microbiome, which is thought to play...
Resource Type:: Article
Full Text:: . Materials and Methods Study Site and Experimental Design The Florida Keys Reef Tract consists of a large

ScholarsArchive@OSU

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Ultrastructural study of spontaneous orocutaneous papillomas of brown bullheads Ictalurus nebulosus

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Organelle trafficking of chimeric ribozymes and genetic manipulation of mitochondria

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Analysis of the genome of leporid herpesvirus 4

Sequence and comparative analysis of the genome of HSV-1 strain McKrae

Survey of Parasites In Threatened Stocks of Coho Salmon (Oncorhynchus kisutch) In Oregon By Examination of Wet Tissues and Histology

Apophallus microsoma N. SP. from Chicks Infected with Metacercariae from Coho Salmon (Oncorhynchus kisutch ) and Review of the Taxonomy and Pathology of the Genus Apophallus (Heterophyidae)

Macroalgae Decrease Growth and Alter Microbial Community Structure of the Reef-Building Coral, Porites astreoides

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