Index Catalog // ScholarsArchive@OSU

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Creator:: Rodriguez-Mari, Adriana, Wilson, Catherine, Titus, Tom A., Canestro, Cristian, BreMiller, Ruth A., Yan, Yi-Lin, Nanda, Indrajit, Johnston, Adam, Kanki, John P., Gray, Erin M., He, Xinjun, Spitsbergen, Jan, Schindler, Detlev, and Postlethwait, John H.
Abstract:: Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that...
Resource Type:: Article
Full Text:: pgen.1001357 1..20 Roles of brca2 (fancd1) in Oocyte Nuclear

Host cell nuclear involvement in vaccinia virus replication

Creator:: Villarreal, Elcira C.
Abstract:: It was previously shown that vaccinia virus is unable to complete its replicative cycle in cells that have been subjected to cytochalasin-B mediated enucleation prior to infection. Likewise, in the presence of the drug α-amanitin, a potent inhibitor of host RNA polymerase II but not of viral transcription, the replication...
Resource Type:: Dissertation
Full Text:: REPLICATING INDEPENDENTLY OF THE HOST CELL NUCLEUS 8 Summary 9 Introduction 10 Methods and Materials 13

Photosynthetic Energy Allocation Strategies of Thalassiosira pseudonana During Light Limited Growth

Creator:: Fisher, Nerissa L.
Abstract:: Photosynthetic energy allocation strategies were investigated in the marine diatom, Thalassiosira pseudonana, grown under a wide range of light limitation. Steady-state, continuous cultures were established at three light-limited growth rates. Simultaneous measurements of photosynthetic activity were made that targeted different points in photosynthetic energy flow from gross to net photosynthesis....
Resource Type:: Masters Thesis
Full Text:: summary, the nuclear genome contained 34 million base pairs composed of 24 diploid chromosomes, the

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Creator:: Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, del Pilar Lopez Pazmino, Maria, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, and Stainier, Didier Y. R.
Abstract:: Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-catenin. To...
Resource Type:: Article
Full Text:: ): e1005305. doi:10.1371/journal. pgen.1005305 Editor: Mary C. Mullins, University of Pennsylvania School of

Novel Experimental Designs and Mathematical Models to Study Fecal Indicator Bacteria Persistence in Surface Water

Creator:: Brooks, Lauren
Abstract:: High counts of fecal indicators, used to signal the potential presence of pathogens associated with untreated waste, result in the classification of water bodies throughout the United States as impaired. Nonpoint sources of unknown origin that contribute to fecal contamination make management of impaired waters challenging, as they are difficult...
Resource Type:: Dissertation
Full Text:: decay, studies using ruminant sources of fecal material are underrepresented in the available data

Growth and development of tetracycline resistant Chlamydia suis

Creator:: Lenart, Jennifer
Abstract:: Tetracycline is a front line antibiotic for the treatment of chlamydial infections in both humans and animals, and the emergence of tetracycline resistant (tet[superscript R]) Chlamydia is of significant clinical importance. Recently, several tet[superscript R] chlamydial strains have been isolated from swine (Sus scrofa) raised in production facilities in Nebraska....
Resource Type:: Masters Thesis
Full Text:: Livestock 25 III. MATERIALS AND METHODS 29 Cell Culture 29 Chlamydial Infections 29 Production of

Factors affecting the Ceratomyxa shasta infectious cycle and transmission between polychaete and salmonid hosts

Creator:: Bjork, Sarah J.
Abstract:: Ceratomyxa shasta is a myxozoan parasite that infects salmonid fishes causing the disease ceratomyxosis that is characterized by severe hemorrhage and necrosis of the intestine and death of the fish host. Ceratomyxa shasta is endemic to the Pacific Northwestern United States and Canada, where epizootics are reported for both wild...
Resource Type:: Dissertation
Full Text:: immunological techniques. Journal of Fish Diseases 12, 509-522. Bartholomew, J.L., Whipple, M.J., Stevens

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...
Resource Type:: Article
Full Text:: of oncogenic krasV12 on liver development is shown in more detail in supplementary material Fig. S1

Analysis of the genome of leporid herpesvirus 4

Creator:: Babra, Bobby, Watson, Gregory, Xu, Wayne, Jeffrey, Brendan, Xu, Jia-Rong, Rockey, Dan, Rohrmann, George, and Jin, Ling
Abstract:: The genome of a herpesvirus highly pathogenic to rabbits, leporid herpesvirus 4 (LHV-4), was analyzed using high-throughput DNA sequencing technology and primer walking. The assembled DNA sequences were further verified by restriction endonuclease digestion and Southern blot analyses. The total length of the LHV-4 genome was determined to be about...
Resource Type:: Article
Full Text:: stands for the bootstrap value of 100. For details see Materials and Methods. 437 438 Supplemental

Sequence and comparative analysis of the genome of HSV-1 strain McKrae

Creator:: Watson, G., Xu, W., Reed, A., Babra, B., Putman, T., Wick, E., Wechsler, S., Rohrmann, G. F., and Jin, L.
Abstract:: Ocular infection by HSV-1 strain McKrae is neurovirulent in both mice and rabbits and causes fatal encephalitis in approximately 50% of animals. In addition, it spontaneously reactivates with high frequency relative to other HSV-1 strains in rabbits. We sequenced the McKrae strain genome and compared its coding protein sequences with...
Resource Type:: Article
Full Text:: block of substitutions present in McKrae is adjacent to the nuclear localization signal (NLS) (amino

ScholarsArchive@OSU

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Host cell nuclear involvement in vaccinia virus replication

Photosynthetic Energy Allocation Strategies of Thalassiosira pseudonana During Light Limited Growth

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Novel Experimental Designs and Mathematical Models to Study Fecal Indicator Bacteria Persistence in Surface Water

Growth and development of tetracycline resistant Chlamydia suis

Factors affecting the Ceratomyxa shasta infectious cycle and transmission between polychaete and salmonid hosts

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Analysis of the genome of leporid herpesvirus 4

Sequence and comparative analysis of the genome of HSV-1 strain McKrae

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