Index Catalog // ScholarsArchive@OSU

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: thank Dr. Daniel W. Schafer of the Department of Statistics and Dr. Thomas F. Savage of the Department

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: non-disintegrating hydrophilic matrix tablets. Tablets containing 5% and 7.5% HPMC were selected for

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: for subject No.5. following multiple oral administration of commercial APAP tablets at 0, 6, 12, 18

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation
Full Text:: of the capsule shell and release of GRF was also studied. Storage for up to 12 months had no effect

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: concentrations of 5 gg/mL over a 12 hour dosing interval. Evaluation of Gastrointestinal Transit Time and

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Creator:: Laskar, Paul A.
Abstract:: The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
Resource Type:: Dissertation
Full Text:: addition, evidence for the presence of general acid catalysis and no evidence for general base catalysis

Calcium alginate gels in oral dosage form design

Creator:: Lin, Shun Yih
Abstract:: In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
Resource Type:: Dissertation
Full Text:: study (first 6-week period). SUBLECT TC1 HDL2 TRI3 LDL4 RATIOS NO. GROUP-2 (placebo treated, F

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Creator:: Sorasuchart, Waranush
Resource Type:: Dissertation
Full Text:: 2.5* 2 12 0.0830 0.0130 5 5.0 2 13 0.1740 0.0260 5 5.0 2 Note: DSPC represents distearoyl

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: using a pharmacokinetic model. It was concluded that there was no statistically significant difference

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation
Full Text:: Duffy provided valuable technical assistance. I would also like to thank Al Soeldner for his

ScholarsArchive@OSU

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

New product formulation and multiple dose pharmacokinetics of acetaminophen

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Calcium alginate gels in oral dosage form design

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

New acetaminophen products : formulation development and bioavailability

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