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  • New product formulations, pharmacokinetics and bioavailability of dyphylline

    Creator:
    Chang, Shyi-Feu
    Abstract:
    Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
    Resource Type:
    Dissertation
    Full Text:
    rpm) A.14 % Dyphylline unreleased vs. square root of 278 elapsed time from 10% paraffin coated of

  • Preparing sustained release dosage forms of nifedipine by hot-melt coating method

    Creator:
    Le, Hang Thi
    Abstract:
    A nifedipine sustained release dosage form was prepared by using hot-melt batch coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and carnauba wax were coating agents used to make single layer coated beads and multiple layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
    Resource Type:
    Masters Thesis
    Full Text:
    ..................................... 7 Available dosage form ............................... 14 Development a nifedipine sustained

  • Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

    Creator:
    Kwon, Hyojong
    Abstract:
    This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
    Resource Type:
    Dissertation
    Full Text:
    LIST OF TABLES Table 1.1. Amount and sort of excipients for GRD 14 1.2. Formulation of

  • Formulation and pharmacokinetics of melatonin

    Creator:
    Konsil, Julraht
    Resource Type:
    Dissertation
    Full Text:
    AUC (0-t h, pg h/ml) and total 210 6STMT urinary excretion (0-t h, 14) following oral administration

  • Development and in vivo testing of a gastric retention device (GRD) in dogs

    Creator:
    Kapsi, Shivakumar G.
    Abstract:
    This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
    Resource Type:
    Dissertation
    Full Text:
    on drug dissolution 121 111-14 Efforts to decrease the final amount of formulation by varying The

  • Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

    Creator:
    Keller, Carol Ann
    Abstract:
    Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
    Resource Type:
    Dissertation
    Full Text:
    ............................................ 48 1.9 Percent Yield of Granules in the 14-20 Mesh Range for Three GranulationMethods