Index Catalog // ScholarsArchive@OSU

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation
Full Text:: Hypertensive Patients. Abstract Approved: James W This thesis describes in vitro and in vivo evaluation of a

Creator:: Kwon, Hyojong
Abstract:: This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
Resource Type:: Dissertation
Full Text:: /PHARMACODYNAMIC MODELING/SIMULATION AND NOVEL GASTRIC RETENTION FORMULATION. Abstract approved: James W. Ayres

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: and the enormous feeling of gratefulness for Dr. James Ayres who is my major professor and my advisor

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: Osteoarthritis Patients. Abstract approved: James W. Ayres Acetaminophen has been safely used for analgesia

ScholarsArchive@OSU