Index Catalog // ScholarsArchive@OSU

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: ..................................................................................... 125 2.19 Summary of pharmacokinetic parameters resulting from fitting 7.5% F[PMC Sustained Release

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: FIGURES (continued) Page IV-2 a-f Individual itraconazole plasma concentration-time curve for 6 subjects

Creator:: Sorasuchart, Waranush
Resource Type:: Dissertation
Full Text:: nicardipine HC1 60 mg capsules 107 V.1-a-f Individual nicardipine HC1 plasma concentration-time curve 123

Creator:: Konsil, Julraht
Resource Type:: Dissertation
Full Text:: Profile Of SR MT Formulation (10% IR MT + 90% SR MT), And Plots Of CL/F And Vd/F Versus Age Following

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation
Full Text:: Effects of compaction and crushing on drug release for formulation F (Surelease®) (n=3

ScholarsArchive@OSU