Index Catalog // ScholarsArchive@OSU

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: within the therapeutic range (15-20mg/L). The remaining fifty percent of the patients required

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: ............................................................................................................. 19 l.3D Simulated Plasma Concentrations for 1000mg of Acetaminophen Every4 Hours

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Creator:: Sorasuchart, Waranush
Resource Type:: Dissertation
Full Text:: nicardipine HC1 containing Eudragit® L 30 D in citrate buffer (pH 4.5) 96 IV.7 Dissolution profiles of

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: release rate dm/dt is governed by dm/dt = ADKLC/L (32), where A is the area, D is the diffusion

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: appreciation to Dr. Myrna Munar and Dr. Sandra Earle who where the main key players in my projects and who

Formulation and pharmacokinetics of melatonin

Creator:: Konsil, Julraht
Resource Type:: Dissertation
Full Text:: beads or 9% Eudragit® L 30D coated on 20% Aquacoat® coated beads were orally given to the subjects (all

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation

ScholarsArchive@OSU

The study of pharmacokinetics in a clinical environment

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Development and in vivo testing of a gastric retention device (GRD) in dogs

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

New product formulations, pharmacokinetics and bioavailability of dyphylline

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Formulation and pharmacokinetics of melatonin

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

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