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Filtering by: Creator Richman, James G. Remove constraint Creator: Richman, James G. Advisor Ayres, James W. Remove constraint Advisor: Ayres, James W.

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  • Development and in vivo testing of a gastric retention device (GRD) in dogs

    Creator:
    Kapsi, Shivakumar G.
    Abstract:
    This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
    Resource Type:
    Dissertation
    Full Text:
    DEVICE Shivakumar G. Kapsi and James W. Ayres 6 ABSTRACT In an effort to increase gastric retention

  • New product formulation and multiple dose pharmacokinetics of acetaminophen

    Creator:
    Sahajwalla, Chandrahas G.
    Abstract:
    Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
    Resource Type:
    Dissertation
    Full Text:
    pharmacokinetics of acetaminophen AN ABSTRACT OF THE THESIS OF Chandrahas G. Saha.iwalla for the degree of

  • Antimicrobial vaginal dosage forms employing Dimethyl Fumarate or propionic acid

    Creator:
    Sahajwalla, Chandrahas G.
    Abstract:
    Propionic acid, live Propionibacterium shermanii, and Dimethyl Fumarate (DMF) were tested for their stimulatory or inhibitory efects on yeast, bacteria, and molds. The amount of propionic acid required for inhibition of molds was strain specific and equal to or less than that required for inhibition of the yeasts. Live P....
    Resource Type:
    Masters Thesis
    Full Text:
    Fumarate or propionic acid AN ABSTRACT OF THE THESIS OF Chandrahas G. Sahajwalla for the degree of

  • Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

    Creator:
    Keller, Carol Ann
    Abstract:
    Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
    Resource Type:
    Dissertation
    Full Text:
    Osteoarthritis Patients. Abstract approved: James W. Ayres Acetaminophen has been safely used for analgesia

  • Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

    Creator:
    Huang, Hua-pin
    Abstract:
    Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
    Resource Type:
    Dissertation
    Full Text:
    prodrug dissolution in the G-I tract. This characteristic of dyphylline prodrugs may provide a stratagem

  • Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

    Creator:
    Yang, Ning-Ning
    Abstract:
    This thesis describes a novel "Tablet-in-a-Bottle" oral suspension formulation. Ingredients with unstable physical or chemical characteristics can be placed in a core tablet, and then dry compression coated with an outer layer which provides separation from other components. The new suspension formulation comprises fast disintegrating clavulanic acid (KCA) tablets with...
    Resource Type:
    Masters Thesis
    Full Text:
    . CONTRIBUTION OF AUTHORS Dr. James Ayres was involved in the formulation design, data interpretation, and

  • Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

    Creator:
    Lorskulsint, Duangchit
    Abstract:
    The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
    Resource Type:
    Masters Thesis
    Full Text:
    stable salts and the free base is only slightly water soluble (1 g; 2500 ml. ). Ointments

  • Calcium alginate gels in oral dosage form design

    Creator:
    Lin, Shun Yih
    Abstract:
    In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
    Resource Type:
    Dissertation
    Full Text:
    for Privacy James W. Ayres, Ph.D. In vivo research following ingesting of commercially available

  • Bioadhesive polymers in drug product formulations

    Creator:
    Tavipatana, Wattanaporn
    Abstract:
    Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
    Resource Type:
    Dissertation
    Full Text:
    approved: _Redacted for Privacy ((/ James W. Ayres, Ph /. / Gastric retention time of single unit dosage

  • Formulation studies of lactic acid-producing bacteria for oral administration

    Creator:
    Liou, Yow-Hwa Grace
    Abstract:
    Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
    Resource Type:
    Dissertation
    Full Text:
    oral administration AN ABSTRACT OF THE THESIS OF Yow-Hwa G. Liou for the degree of Doctor of