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  • New product formulations, pharmacokinetics and bioavailability of dyphylline

    Creator:
    Chang, Shyi-Feu
    Abstract:
    Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
    Resource Type:
    Dissertation
    Full Text:
    % Dyphylline unreleased from dyphylline- 45 ethylcellulose (100 cps) microcapsules in acid-pretreatment

  • Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

    Creator:
    Kwon, Hyojong
    Abstract:
    This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
    Resource Type:
    Dissertation
    Full Text:
    (g) Weight % Sugar (20-mesh) 40 45 Hydrochlorothiazide 40 45 HPC (Krucel®) 3 3 PVP (Povidone® K-30

  • Preparing sustained release dosage forms of nifedipine by hot-melt coating method

    Creator:
    Le, Hang Thi
    Abstract:
    A nifedipine sustained release dosage form was prepared by using hot-melt batch coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and carnauba wax were coating agents used to make single layer coated beads and multiple layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
    Resource Type:
    Masters Thesis
    Full Text:
    three categories (45): Improvement of palatability of the dosage form. Prevention of environmental

  • Development and in vivo testing of a gastric retention device (GRD) in dogs

    Creator:
    Kapsi, Shivakumar G.
    Abstract:
    This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
    Resource Type:
    Dissertation
    Full Text:
    Gastric Retention Device in dogs 45 Abstract Introduction Experimental Results and discussion

  • Formulation and pharmacokinetics of melatonin

    Creator:
    Konsil, Julraht
    Resource Type:
    Dissertation
    Full Text:
    ) with half lives of about 2-5 minutes and 45 minutes, respectively(23, 28, 29, 30). Systemic clearance

  • Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

    Creator:
    Keller, Carol Ann
    Abstract:
    Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
    Resource Type:
    Dissertation
    Full Text:
    Formulations ............................................................................... 45 1.13 Effect of