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Formulation and pharmacokinetics of melatonin

Creator:: Konsil, Julraht
Resource Type:: Dissertation
Full Text:: Melatonin. Abstract approved: Abstract approved: Keith A. Parrott Pharmacokinetics following oral

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: . 22. Sullivan TJ, Sakmar E, Wagner JG. Comparative bioavailability: A new type of in vitro - in vivo

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: SimulationlModeling as a Tool for Therapeutic Drug Monitoring and Dose Adjustment in Special Patient Populations

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: Development and Testing of a Sustained Release Acetaminophen

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

Creator:: Bani Jaber, Ahmad Kh.
Abstract:: This thesis is compromised of two distinct formulation sections, which are described below: New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic...
Resource Type:: Dissertation
Full Text:: Formulation and in vitro-in vivo evaluation of a new

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: formulation and 507 in vitro dyphylline released within the first hour from a polymer matrix formulation

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: unknown input functions, procedure like the Wagner-Nelson method(21), Loo-Riegelman method(22) or a

The absolute bioavailability of dyphylline tablets in human subjects

Creator:: Huston, Thomas K.
Abstract:: Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
Resource Type:: Masters Thesis
Full Text:: and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: saliva acetaminophen concentration vs time normalized to a 325 mg dose were superimposable, indicating

Comparative pharmacokinetic studies of dyphylline and some dyphylline prodrugs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analog of theophylline and the latter is the most popular member of the methylxanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life has made it's clinical usefulness limited. To avoid this problem a...
Resource Type:: Masters Thesis
Full Text:: dyphylline is devoid of some problems associated with theophylline, a reported short half-life has made

ScholarsArchive@OSU

Formulation and pharmacokinetics of melatonin

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

New product formulations, pharmacokinetics and bioavailability of dyphylline

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

The absolute bioavailability of dyphylline tablets in human subjects

New product formulation and multiple dose pharmacokinetics of acetaminophen

Comparative pharmacokinetic studies of dyphylline and some dyphylline prodrugs

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