Mycobacterium avium subsp. hominissuis (MAH) is a nontuberculous mycobacterium which commonly infects patients with underlying lung pathology. MAH infections are difficult to treat and require lengthy courses of multiple antibiotics. MAH infects macrophages and evade the immune system by altering host cell cytokine production. The hypothesis is that intracellular MAH...
Mycobacterium avium subsp. hominissuis (MAH) is a common environmental bacterium that causes infections in immunocompromised patients such as those with HIV/AIDS, or patients with chronic lung disease such as Cystic Fibrosis. There are many strains of MAH with varying levels of virulence. Infection with MAH strains 100 and 104 have...
M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...
A primary target of Mycobacterium tuberculosis is the human alveolar macrophage.
Infection by this bacterium can lead to a variety of responses, such as apoptosis,
autophagy, and necrosis, which may be involved in controlling the infection. M.
tuberculosis has evolved mechanisms to evade or use the host-mediated processes to its...
M. avium subsp. hominissuis (MAH) and M. abscessus subsp. abscessus (MAB) both belong to the clinically important non-tuberculous mycobacterial (NTM) group that infect immunocompromised patients with AIDS and individuals with underlining lung conditions such as bronchiectasis or cystic fibrosis. The main challenge of treating MAH and MAB patients is an...
Environmental mycobacteria are important opportunistic pathogens for many hosts,
including humans, cattle, and fish. Two well-studied species are Mycobacterium
avium subsp. avium, a significant cause of disseminated bacterial disease in patients
with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s
disease in cattle. Many other species that are...