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  • Size criterion for intercalation of hydrocarbon in DNA

    Creator:
    Craig, Albert Morrie
    Abstract:
    The binding of fifteen hydrocarbons to native DNA has been investigated. The hydrocarbons were chosen to test a size criterion for hydrocarbon - DNA complexes. It has been found that hydrocarbons, which are small enough to intercalate between the base pairs of a distorted Watson - Crick model of DNA,...
    Resource Type:
    Masters Thesis

  • Intercalation on hydrocarbons in polynucleotides

    Creator:
    Craig, Albert Morrie
    Abstract:
    The binding of eleven polycyclic, aromatic hydrocarbons to the acid form of poly A has been investigated. The hydrocarbons were chosen to test a size criterion. Model building showed that some hydrocarbons could intercalate in the helix and be well protected from contact with the aqueous solvent. Experimentally it was...
    Resource Type:
    Dissertation