Index Catalog // ScholarsArchive@OSU

The Role of Syndecan-1 in Arterial Mechanotransduction

Creator:: Steyer, Benjamin G.
Abstract:: Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
Resource Type:: Honors College Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Benjamin G. Steyer for

The Role of Syndecan-1 in Arterial Mechanotransduction.

Creator:: Steyer, Benjamin G.
Abstract:: Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
Resource Type:: Honors College Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Benjamin G. Steyer for

Surfactant Effects on Adsorption of Recombinant Factor VIII (rFVIII) at the Air-Water Interface

Creator:: Gray, Warren D.
Abstract:: The primary goal was to characterize the adsorption of a recombinant therapeutic protein in the presence of selected surfactant species at the air-water interface. For this purpose, dynamic interfacial tensiometry was used to determine the surface tension kinetics exhibited by protein solutions containing either Tween 80 or the poly[ethylene oxide]-...
Resource Type:: Honors College Thesis
Full Text:: contact angle of liquid on the probe (John Davies, 1996). The probes used are prepared so that they are

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Creator:: Ryder, Matthew P.
Abstract:: While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
Resource Type:: Masters Thesis

Nisin adsorption and function at hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock surfactant Pluronic® F108

Creator:: Tai, Yuan-Ching
Abstract:: The adsorption and elution of the antimicrobial peptide nisin at hydrophobic, silanized silica surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]- poly[ethylene oxide] surfactant Pluronic® F108 was measured in situ, with ellipsometry. While such layers are known to inhibit protein adsorption, nisin was observed to adsorb in multilayer quantities, to an...
Resource Type:: Dissertation
Full Text:: specific volume of 3.837 mL/g and a molecular weight to molar refractivity ratio of 0.729 g/mL. Each

Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

Creator:: Auxier, Julie A.
Abstract:: Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
Resource Type:: Masters Thesis
Full Text:: .; Hubbell, J. A.; Spencer, N. D., Poly(L-lysine)-g-poly(ethylene glycol) Layers on Metal Oxide Surfaces

Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

Creator:: Lee, Hyo Jin
Abstract:: Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages of the derivatization. Xray photoelectron spectroscopy was used to analyze the elemental composition of the surface at each step of immobilizing heparin as well and...
Resource Type:: Masters Thesis
Full Text:: adsorption of human serum albumin (HSA), immunoglobulin G (IgG), and fibrinogen at a hydrophobic surface

Molecular origins of peptide entrapment in polyethylene oxide layers

Creator:: Wu, Xiangming
Abstract:: A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
Resource Type:: Dissertation
Full Text:: suspension of hydrophobic silica nanoparticles (R816, Degussa, 190 m2/g, 10-12 nm) in Pluronic® F108 (BASF

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Creator:: Joshi, Pranav R.
Abstract:: Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...
Resource Type:: Dissertation

Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

Creator:: Ryder, Matthew P.
Abstract:: Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
Resource Type:: Dissertation

ScholarsArchive@OSU

The Role of Syndecan-1 in Arterial Mechanotransduction

The Role of Syndecan-1 in Arterial Mechanotransduction.

Surfactant Effects on Adsorption of Recombinant Factor VIII (rFVIII) at the Air-Water Interface

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Nisin adsorption and function at hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock surfactant Pluronic® F108

Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

Molecular origins of peptide entrapment in polyethylene oxide layers

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

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