Index Catalog // ScholarsArchive@OSU

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Creator:: Joshi, Pranav R.
Abstract:: Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Pranav R. Joshi for the

Adsorption of selected charge mutants of bacteriophage T4 lysozyme at silanized silica surfaces

Creator:: Podhipleux, Nilobon
Abstract:: The adsorption kinetics exhibited by selected charge mutants of T4 lysozyme at silanized silica surfaces were monitored with in situ ellipsometry. Mutant lysozymes were produced by substitution of lysine (Lys) with glutamic acid (Glu). Each substitution resulted in a decrease in the net charge of the protein by 2 units....
Resource Type:: Masters Thesis
Full Text:: APPROVED: Major-'PrDfass^r, representing Food Science & Technology HeacmDepartment of Food Science

Synthesis and evaluation of PEO-coated materials for microchannel-based hemodialysis

Creator:: Heintz, Keely
Abstract:: The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work, stable surface modifications with pendant polyethylene oxide (PEO) chains were produced on polycarbonate...
Resource Type:: Masters Thesis
Full Text:: : _________________________________________________________________________ Joseph McGuire The marked increase in surface-to-volume ratio associated with

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Creator:: Ryder, Matthew P.
Abstract:: While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
Resource Type:: Masters Thesis
Full Text:: approved: ________________________________________________________________________ Joseph McGuire

Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

Creator:: Joshi, Omkar
Abstract:: Adipic dihydrazide-modified heparin was prepared and subsequently immobilized on surface-activated silica wafers. X-ray photoelectron spectroscopy (XPS) was used to quantify the elemental composition of the silica surface at each stage of activation and results showed that successful immobilization had taken place. Contact angle measurements were made to verify the high...
Resource Type:: Masters Thesis
Full Text:: , its precise structure remains unknown (Islam, 2003; Capila, 2002) CH2oso 3• R:02· 0

Molecular properties influencing the surface activity of α-lactalbumin, β-lactoglobulin and bovine serum albumin

Creator:: Suttiprasit, Prasert
Resource Type:: Dissertation
Full Text:: Albumin Abstract approved: 7 /I#r. Joseph McGuire The thermal stability of a-lactalbumin

Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

Creator:: Lee, Hyo Jin
Abstract:: Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages of the derivatization. Xray photoelectron spectroscopy was used to analyze the elemental composition of the surface at each step of immobilizing heparin as well and...
Resource Type:: Masters Thesis
Full Text:: two regions. The two outer D domains consist of {3 and r compactly folded chains while a hydrophilic

Elution of adsorbed proteins at hydrophobic and hydrophilic surfaces by dodecyltrimethylammonium bromide and sodium dodecyls sulfate

Creator:: Vinaraphong, Pravina
Abstract:: Adsorption kinetic data recorded for α-lactalbumin, β-casein, β-lactoglobulin, bovine serum albumin and lysozyme at silianized silica surfaces of low and high hydrophobicity, along with a simple model for adsorption and surfactant-mediated elution of protein, were used to analyze the removal of each protein by sodium dodecylsulfate (SDS) and dodecyltrimethylammonium bromide...
Resource Type:: Masters Thesis
Full Text:: Dodecyls Sulfate Abstract approved: -i—*■*=—i- "t Joseph McGuire Adsorption kinetic data recorded

Interaction of recombinant factor VIII and the nonionic surfactant Tween 80 at interfaces

Creator:: Joshi, Omkar
Abstract:: The role of the nonionic surfactant Tween 80 on the behavior of the therapeutic recombinant protein Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a model system to compare results obtained for the complicated rFVIII-Tween system, a well-characterized globular protein lysozyme was used. The...
Resource Type:: Dissertation
Full Text:: and Joseph McGuiret Department of Chemical Engineering, Oregon State University, Corvallis OR 97331

Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

Creator:: Fry, Allyson Kaye
Abstract:: Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
Resource Type:: Masters Thesis
Full Text:: approved: _____________________________________________________________________ Joseph McGuire

ScholarsArchive@OSU

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Adsorption of selected charge mutants of bacteriophage T4 lysozyme at silanized silica surfaces

Synthesis and evaluation of PEO-coated materials for microchannel-based hemodialysis

Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

Molecular properties influencing the surface activity of α-lactalbumin, β-lactoglobulin and bovine serum albumin

Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

Elution of adsorbed proteins at hydrophobic and hydrophilic surfaces by dodecyltrimethylammonium bromide and sodium dodecyls sulfate

Interaction of recombinant factor VIII and the nonionic surfactant Tween 80 at interfaces

Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

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