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  • Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects

    Creator:
    Lee, Hyo Jin
    Abstract:
    Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages of the derivatization. Xray photoelectron spectroscopy was used to analyze the elemental composition of the surface at each step of immobilizing heparin as well and...
    Resource Type:
    Masters Thesis
    Full Text:
    ................................. 61 B NMR analysis of modified heparin........................ 64 C Toluidine Blue Assay-Detection

  • Interaction of recombinant factor VIII and the nonionic surfactant Tween 80 at interfaces

    Creator:
    Joshi, Omkar
    Abstract:
    The role of the nonionic surfactant Tween 80 on the behavior of the therapeutic recombinant protein Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a model system to compare results obtained for the complicated rFVIII-Tween system, a well-characterized globular protein lysozyme was used. The...
    Resource Type:
    Dissertation
    Full Text:
    and Joseph McGuiret Department of Chemical Engineering, Oregon State University, Corvallis OR 97331

  • Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects

    Creator:
    Joshi, Omkar
    Abstract:
    Adipic dihydrazide-modified heparin was prepared and subsequently immobilized on surface-activated silica wafers. X-ray photoelectron spectroscopy (XPS) was used to quantify the elemental composition of the silica surface at each stage of activation and results showed that successful immobilization had taken place. Contact angle measurements were made to verify the high...
    Resource Type:
    Masters Thesis
    Full Text:
    .................................................... 77 C NMR analysis of adipic dihydrazide-modified heparin

  • Human platelet adhesion to heparinized silica surfaces

    Creator:
    Bolsinger, Travis Samuel Sebastian
    Abstract:
    Heparin was modified and immobilized to surface-activated silica surfaces using two different reaction schemes. End-aminated heparin was reacted with 2-iminothiolane to produce free thiol groups at the terminal ends of the heparin chains. The end-thiolated heparin was immobilized by reaction with a pyridyl disulfide activated poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock...
    Resource Type:
    Masters Thesis
    Full Text:
    : _____________________________________________________________________ Joseph McGuire Heparin was modified and immobilized to surface-activated silica surfaces

  • Kinetic modeling of the adsorption of structural stability mutants of bacteriophage T4 lysozyme at solid-water interfaces

    Creator:
    Lee, Woo-Kul
    Resource Type:
    Dissertation
    Full Text:
    my major professor, Dr. Joseph McGuire for his support, encourage, and endowing me so many

  • Molecular Origins of Recombinant Factor VIII (rFVIII)

    Creator:
    Tadehara, Katherine M.
    Abstract:
    The capability of Pluronic® F68 to stabilize human recombinant Factor VIII in solution was assessed using zeta potential measurements. Hemophilia A is a genetic disorder in which the body is missing Factor VIII (FVIII) from the blood coagulation cascade. The pharmaceutical industry developed recombinant Factor VIII (rFVIII), the largest cloned...
    Resource Type:
    Honors College Thesis
    Full Text:
    : Joseph Maguire The capability of Pluronic® F68 to stabilize human recombinant Factor VIII in solution

  • Quantification of fibrinogen adsorption to nisin-loaded polyethylene oxide layers

    Creator:
    Auxier, Julie A.
    Abstract:
    Antimicrobial coatings used to reduce the risk of infection caused by tissue-contacting medical devices must address specific biocompatibility requirements including prevention of thrombosis and rise of bacterial resistance. An antimicrobial-loaded poly(ethylene-oxide) (PEO) coating has been tentatively shown to be non-fouling with sustained antimicrobial activity. However, the presence of the antimicrobial,...
    Resource Type:
    Honors College Thesis
    Full Text:
    layers. Abstract approved: _______________________________________________________ Joseph

  • Surfactant interactions with recombinant factor VIII at the air/water interface

    Creator:
    Chu, Liping
    Abstract:
    The surface tension kin'ti4tnd ste'dy state behavior exhibited by mixtures of selected surfactants with a recombinant Factor VIII (rFVIII) were evaluated with automated interfacial tensiometry. In particular, fresh solutions of rFVIII with different concentrations of Tween 80, sodium dodecylsulfate (SDS), or dodecyltrimethylammonium bromide (DTAB) were prepared and their surface tension...
    Resource Type:
    Masters Thesis
    Full Text:
    I sincerely express my gratitude to Dr. Joseph McGuire, my major professor, for giving me this

  • The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

    Creator:
    Alkhatib, Aveen K.
    Abstract:
    The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
    Resource Type:
    Masters Thesis
    Full Text:
    : _____________________________________________________________________ Joseph McGuire The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the

  • Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

    Creator:
    Fry, Allyson Kaye
    Abstract:
    Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: _____________________________________________________________________ Joseph McGuire