Index Catalog // ScholarsArchive@OSU

Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

Creator:: Ryder, Matthew P.
Abstract:: Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
Resource Type:: Dissertation

Molecular origins of peptide entrapment in polyethylene oxide layers

Creator:: Wu, Xiangming
Abstract:: A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
Resource Type:: Dissertation

Synthesis of gold nanoparticle surfactants and their self-assembly at oil-water interfaces

Creator:: Truong, Mitchell
Abstract:: Amphiphilic gold nanoparticle surfactants can self-assemble at oil-water interfaces to form stable Pickering emulsions. These nanoparticle surfactants have previously been synthesized by functionalizing gold nanoparticles with thiol terminated polyethylene glycol (PEG-thiol), and subsequently with an alkane-thiol. It is necessary to improve the bio-compatibility of the nanoparticles if they are to...
Resource Type:: Honors College Thesis

Characterization and application of PEO-containing triblock copolymer surfactants

Creator:: Snider, Joshua L.
Abstract:: The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
Resource Type:: Honors College Thesis

Temperature effects on surface energetic parameters evaluated at solid/liquid interfaces

Creator:: Lee, Euisang
Abstract:: Measurable surface parameters which may be related to the response evoked upon contact with biofluids have been suggested to provide direction for characterization, prediction, and ultimate control of biofluid behavior at interfaces. With respect to fouling of heat exchange equipment by biofluids, such properties may be useful for the development...
Resource Type:: Masters Thesis

The effect of pH and ionic strength on the adsorption of β-lactoglobulin onto well-characterized silicon

Creator:: Luey, Ja-Kael
Abstract:: The effect of pH and ionic strength on the equilibrium adsorptive behavior of β-lactoglobulin onto hydrophobic and hydrophilic silicon surfaces was studied using ellipsometry. Plots of amount adsorbed (μg protein/cm²) as a function of protein concentration (mg/ml) exhibited attainment of plateau values beyond a protein concentration of 0.250 mg/ml. At...
Resource Type:: Masters Thesis

β-Lactoglobulin adsorption equilibrium at low- and high-energy surfaces

Creator:: Al-Malah, Kamal Issa Masoud
Abstract:: Ellipsometry was used to study the effects of surface energetics and temperature on the equilibrium adsorptive behavior exhibited by β-lactoglobulin. β-Lactoglobulin isotherms at 25, 37, and 55°C were constructed for this purpose. The surfaces of acrylic, polycarbonate, polyester, glass, and #304 stainless steel were contacted with protein solutions of varying...
Resource Type:: Masters Thesis

Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

Creator:: Auxier, Julie A.
Abstract:: Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
Resource Type:: Masters Thesis

Adsorption of synthetic stability mutants of bacteriophage T4 lysozyme at silanized silica surfaces

Creator:: Singla, Brijesh
Resource Type:: Masters Thesis

Macroscopic model for apparent protein adsorption equillibrium at hydrophobic solid-water interfaces

Creator:: Al-Malah, Kamal Issa Masoud
Resource Type:: Dissertation

ScholarsArchive@OSU

Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

Molecular origins of peptide entrapment in polyethylene oxide layers

Synthesis of gold nanoparticle surfactants and their self-assembly at oil-water interfaces

Characterization and application of PEO-containing triblock copolymer surfactants

Temperature effects on surface energetic parameters evaluated at solid/liquid interfaces

The effect of pH and ionic strength on the adsorption of β-lactoglobulin onto well-characterized silicon

β-Lactoglobulin adsorption equilibrium at low- and high-energy surfaces

Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

Adsorption of synthetic stability mutants of bacteriophage T4 lysozyme at silanized silica surfaces

Macroscopic model for apparent protein adsorption equillibrium at hydrophobic solid-water interfaces

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