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Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:

Page, Jessica M.

Abstract:

An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...

Resource Type:

Honors College Thesis
Investigating the age-related loss of endoplasmic reticulum stress response

Creator:

Fallahi, Anahita

Abstract:

The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...

Resource Type:

Honors College Thesis

Full Text:

development of PD. Considering the typical age of patients diagnosed with PD is around 60, it is clear that