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Filtering by: Subject Ketoconazole -- Mechanism of action Remove constraint Subject: Ketoconazole -- Mechanism of action Committee Member Zabriskie, Mark Remove constraint Committee Member: Zabriskie, Mark

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  • Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

    Creator:
    Abuelizz, Hatem A.
    Abstract:
    This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
    Resource Type:
    Dissertation
    Full Text:
    specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a

  • Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

    Creator:
    Senawong, Thanaset
    Abstract:
    Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
    Resource Type:
    Dissertation
    Full Text:
    catalyzed by member(s) of class I and II HDACs. One possible mechanism is that CTIP proteins may exert ISA