Index Catalog // ScholarsArchive@OSU

Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Creator:: Park, Catherine
Abstract:: The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Resource Type:: Honors College Thesis

Hepatic Gene Expression Patterns in C57BL/6J Mice Fed High-Fat Diets Supplemented with Watermelon Flesh, Arginine, Citrulline, Lycopene, or S-methylmethionine

Creator:: Chen, Mikayla Y.
Abstract:: About one third of Americans have metabolic syndrome, which is characterized by five risk factors related to blood pressure and triglyceride levels and could lead to diabetes and heart disease if left untreated. Watermelon has been shown to exhibit cardioprotective effects due to its high phytochemical content and may act...
Resource Type:: Honors College Thesis

Chemistry and Grit: The Impact of Prerequisites vs Perseverance on Academic Success in Biology

Creator:: Sparks, Kiersten E.
Abstract:: Previous research on academic success in biology has focused on the influence of prerequisite knowledge and cognitive ability as measured by course grades or GPA. More recently, the field has considered the influence of non-cognitive factors such as grit, defined as passion and perseverance for long term goals. Both grit...
Resource Type:: Honors College Thesis

Cloning the zebrafish otoferlin b wildtype and a transmembrane mutant to characterize changes in cellular localization

Creator:: France, Rebecca A.
Abstract:: Otoferlin is a protein that is essential in the process of hearing. Mutations in otoferlin are associated with profound recessive deafness. The long-term goal of the Johnson lab is to understand how otoferlin contributes to hearing and why certain mutations result in deafness. This project sought to characterize the difference...
Resource Type:: Honors College Thesis

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creator:: Jackson, Kendra K.
Abstract:: PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
Resource Type:: Honors College Thesis

Catalysis of Biologically Relevant Chlorination Reactions by Nicotine, and Potential Relevance to Tissue Damage

Creator:: Dolan, Brigh G.
Abstract:: This work is concerned with determining whether nicotine has a role in promoting oxidative damage in human tissue, particularly in lung tissue. This follows from recent reports of a novel lung disease found in some E-cigarette users, characterized by oxidative damage and elevated levels of neutrophils (termed “vaping disease”). It...
Resource Type:: Honors College Thesis

Creation of At This Point, an undergraduate-focused science podcast

Creator:: Puoci, Victor (Tori) M.
Abstract:: At This Point, an undergraduate-focused science podcast, works to expand the accessibility of science by exploring topics that, at this point, may seem too complex to understand. This thesis project describes the process of creating At This Point and demonstrates how the podcast fulfills the criteria of effective science communication....
Resource Type:: Honors College Thesis

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis

The Dynamic Field of Genetic Counseling and How Students Can Best Prepare Themselves

Creator:: Bauder, Malia V.
Abstract:: Genetic counseling, a healthcare profession centered on communicating genetic information to patients and helping them understand it, has been rapidly evolving with the development of genetic sequencing and editing technology over the past decades. Consequently, future and current genetic counselors must address societal and ethical implications, as well as historical...
Resource Type:: Honors College Thesis

Analyzing the molecular basis of increased enduracidin production in Streptomyces fungicidicus

Creator:: Herinckx, Molly A.
Abstract:: Enduracidin is an antibiotic produced by Streptomyces fungicidicus that is effective against Gram-positive bacteria. Previous work identified seventy-eight mutations in an S. fungicidicus strain that produces a significantly higher level of enduracidin than the wild type strain, ATCC 21013. Eleven mutations were analyzed individually to identify those that may contribute...
Resource Type:: Honors College Thesis

Characterization of Fer1L6 lipid binding properties and its expression in cell cycle

Creator:: Chau, Trisha J.
Abstract:: Ferlins are a family of calcium-sensitive proteins involved in fusion and fission membrane trafficking events. There are six ferlin members: dysferlin, otoferlin, myoferlin, Fer1L4, Fer1L5, and Fer1L6. Previous research shows the first three ferlins play a pathophysiological role in humans, while the other three remain uncharacterized. Fer1L6 is one of...
Resource Type:: Honors College Thesis
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ScholarsArchive@OSU

Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Hepatic Gene Expression Patterns in C57BL/6J Mice Fed High-Fat Diets Supplemented with Watermelon Flesh, Arginine, Citrulline, Lycopene, or S-methylmethionine

Chemistry and Grit: The Impact of Prerequisites vs Perseverance on Academic Success in Biology

Cloning the zebrafish otoferlin b wildtype and a transmembrane mutant to characterize changes in cellular localization

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Catalysis of Biologically Relevant Chlorination Reactions by Nicotine, and Potential Relevance to Tissue Damage

Creation of At This Point, an undergraduate-focused science podcast

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

The Dynamic Field of Genetic Counseling and How Students Can Best Prepare Themselves

Analyzing the molecular basis of increased enduracidin production in Streptomyces fungicidicus

Characterization of Fer1L6 lipid binding properties and its expression in cell cycle

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