Index Catalog // ScholarsArchive@OSU

Creator:: Dolan, Brigh G.
Abstract:: This work is concerned with determining whether nicotine has a role in promoting oxidative damage in human tissue, particularly in lung tissue. This follows from recent reports of a novel lung disease found in some E-cigarette users, characterized by oxidative damage and elevated levels of neutrophils (termed “vaping disease”). It...
Resource Type:: Honors College Thesis
Full Text:: ] Individuals with the more common G-allele have higher levels of MPO expression, alongside higher incidence

Creator:: Puoci, Victor (Tori) M.
Abstract:: At This Point, an undergraduate-focused science podcast, works to expand the accessibility of science by exploring topics that, at this point, may seem too complex to understand. This thesis project describes the process of creating At This Point and demonstrates how the podcast fulfills the criteria of effective science communication....
Resource Type:: Honors College Thesis

Creator:: Chau, Trisha J.
Abstract:: Ferlins are a family of calcium-sensitive proteins involved in fusion and fission membrane trafficking events. There are six ferlin members: dysferlin, otoferlin, myoferlin, Fer1L4, Fer1L5, and Fer1L6. Previous research shows the first three ferlins play a pathophysiological role in humans, while the other three remain uncharacterized. Fer1L6 is one of...
Resource Type:: Honors College Thesis
Date Created:
Full Text::  : Structural and Functional Diversity. Protein Sci. 1996, 5 (12), 2375–2390. (3) Redpath, G. M. I

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis
Full Text:: temperature (RT) for 3-7 days, as previously described (Connolly et al., 2013). Hygromycin B (100 g/mL

Creator:: Chen, Mikayla Y.
Abstract:: About one third of Americans have metabolic syndrome, which is characterized by five risk factors related to blood pressure and triglyceride levels and could lead to diabetes and heart disease if left untreated. Watermelon has been shown to exhibit cardioprotective effects due to its high phytochemical content and may act...
Resource Type:: Honors College Thesis
Full Text:: , R. G., Hayden, M. S., & Ghosh, S. (2011). NF-κB, inflammation, and metabolic disease. Cell

Creator:: France, Rebecca A.
Abstract:: Otoferlin is a protein that is essential in the process of hearing. Mutations in otoferlin are associated with profound recessive deafness. The long-term goal of the Johnson lab is to understand how otoferlin contributes to hearing and why certain mutations result in deafness. This project sought to characterize the difference...
Resource Type:: Honors College Thesis
Full Text:: for otoferlin-related deafness. Frontiers in Molecular Neuroscience, 13, 253. Redpath, G. M

Creator:: Jackson, Kendra K.
Abstract:: PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
Resource Type:: Honors College Thesis
Full Text:: 150 rpm at room temperature (RT) for 3-7 days, as previously described [5]. Hygromycin B (100 g/mL

Creator:: Park, Catherine
Abstract:: The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Resource Type:: Honors College Thesis
Full Text:: . Shanle, Scott M. Coyle, Brian D. Strahl, Danica G. Fujimori, John R. Yates, and Hiten D. Madhani

Creator:: Sparks, Kiersten E.
Abstract:: Previous research on academic success in biology has focused on the influence of prerequisite knowledge and cognitive ability as measured by course grades or GPA. More recently, the field has considered the influence of non-cognitive factors such as grit, defined as passion and perseverance for long term goals. Both grit...
Resource Type:: Honors College Thesis

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