Index Catalog // ScholarsArchive@OSU

Lipidomics and H₂¹⁸O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

Creator:: McDougall, Melissa Q., Choi, Jaewoo, Stevens, Jan F., Truong, Lisa, Tanguay, Robert L., and Traber, Maret G.
Abstract:: We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without...
Resource Type:: Article

Mono-Substituted Isopropylated Triaryl Phosphate, a Major Component of Firemaster 550, is an AHR Agonist that Exhibits AHR-Independent Cardiotoxicity in Zebrafish

Creator:: Gerlach, Cory V., Das, Siba R., Volz, David C., Bisson, William H., Kolluri, Siva K., and Tanguay, Robert L.
Abstract:: Firemaster 550 (FM550) is an additive flame retardant mixture used within polyurethane foam and is increasingly found in house dust and the environment due to leaching. Despite the widespread use of FM550, very few studies have investigated the potential toxicity of its ingredients during early vertebrate development. In the current...
Resource Type:: Article
Full Text:: . Gerlach*, Siba R. Das*, David C. Volz†, William H. Bisson*, Siva K. Kolluri* and Robert L. Tanguay*1

A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants

Creator:: Truong, Lisa, Mandrell, David, Mandrell, Rick, Simonich, Michael, and Tanguay, Robert L.
Abstract:: A substantial body of evidence has correlated the human body burdens of some polybrominated diphenyl ether (PBDE) flame retardants with cognitive and other behavioral deficits. Adult zebrafish exhibit testable learning and memory, making them an increasingly attractive model for neurotoxicology. Our goal was to develop a rapid throughput means of...
Resource Type:: Article

De novo synthesis of a sunscreen compound in vertebrates

Creator:: Osborn, Andrew R., Almabruk, Khaled H., Holzwarth, Garrett, Asamizu, Shumpei, LaDu, Jane, Kean, Kelsey M., Karplus, P. Andrew, Tanguay, Robert L., Bakalinsky, Alan T., and Mahmud, Taifo
Abstract:: Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought...
Resource Type:: Article
Full Text:: ., Almabruk, K. H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K. M., ... & Mahmud, T. (2015). De novo

Chronic exposure of killifish to a highly polluted environment desensitizes estrogen–responsive reproductive and biomarker genes

Creator:: Bugel, Sean M., Bonventre, Josephine A., White, Lori A., Tanguay, Robert L., and Cooper, Keith R.
Abstract:: Reproductive and endocrine disruption is commonly reported in aquatic species exposed to complex contaminant mixtures. We previously reported that Atlantic killifish (Fundulus heteroclitus) from the chronically contaminated Newark Bay, NJ, exhibit multiple endocrine disrupting effects, including inhibition of vitellogenesis (yolk protein synthesis) in females and false negative vitellogenin biomarker responses...
Resource Type:: Article
Full Text:: , Robert L. Tanguaya,2, Keith R. Cooperb,2 Affiliations: aDepartment of Environmental and

Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

Creator:: Weber, Daniel N., Hoffmann, Raymond G., Hoke, Elizabeth S., and Tanguay, Robert L.
Abstract:: Developmental bisphenol A (BPA) exposure is associated with adverse behavioral effects, although underlying modes of action remain unclear. Because BPA is a suspected xenoestrogen, the objective was to identify sex-based changes in adult zebrafish social behavior developmentally exposed to BPA (0.0, 0.1 or 1 μM) or one of two control...
Resource Type:: Article
Full Text:: to 0 (0.1% DMSO only = control), 0.1, 1 µM BPA, 0.1 µM 161 E2, or 0.1 µM GSK4716 from 8-120 h post

Toxicity of chlorine to zebrafish embryos

Creator:: Kent, Michael L., Buchner, Cari, Barton, Carrie, and Tanguay, Robert L.
Abstract:: Surface disinfection of fertilized fish eggs is widely used in aquaculture to reduce extraovum pathogens that may be released from brood fish during spawning, and this is routinely used in zebrafish (Danio rerio) research laboratories. Most laboratories use approximately 25-50 ppm unbuffered chlorine solution for 5-10 min. Treatment of embryos...
Resource Type:: Article
Full Text:: , Carrie Barton2 and Robert L. Tanguay2 3 1Department of Microbiology, Oregon State University, Corvallis

Zebrafish assays as developmental toxicity indicators in the green design of TAML oxidation catalysts

Creator:: Truong, Lisa, DeNardo, Matthew A., Kundu, Soumen, Collins, Terrence J., and Tanguay, Robert L.
Abstract:: TAML activators promise a novel water treatment approach by efficiently catalysing peroxide-based degradation of chemicals of high concern at environmental concentrations. Green design ethics demands an exploration of TAML toxicity. Exposure to high concentrations of certain activators caused adverse effects in zebrafish. At typical TAML operational concentrations, development was not...
Resource Type:: Article
Full Text:: Robert L. Tanguay*a Received (in XXX, XXX) Xth XXXXXXXXX 200X, Accepted Xth XXXXXXXXX 200X DOI

Novel liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos

Creator:: Lebold, Katie M., Kirkwood, Jays S., Taylor, Alan W., Choi, Jaewoo, Barton, Carrie L., Miller, Galen W., La Du, Jane, Jump, Donald B., Stevens, Jan Frederik, Tanguay, Robert L., and Traber, Maret G.
Abstract:: To test the hypothesis that embryogenesis depends upon α-tocopherol (E) to protect embryo polyunsaturated fatty acids (PUFAs) from lipid peroxidation, new methodologies were applied to measure α-tocopherol and fatty acids in extracts from saponified zebrafish embryos. A solid phase extraction method was developed to separate the analyte classes, using a...
Resource Type:: Article
Full Text:: , Robert L. Tanguay d,e,f, Maret G. Traber a,b,f,n a Linus Pauling Institute, Oregon State University

Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens

Creator:: Hanigan, David, Truong, Lisa, Schoepf, Jared, Nosaka, Takayuki, Mulchandani, Anjali, Tanguay, Robert L., and Westerhoff, Paul
Abstract:: Both nanoparticulate (nZnO and nTiO(2)) and organic chemical ultraviolet (UV) filters are active ingredients in sunscreen and protect against skin cancer, but limited research exists on the environmental effects of sunscreen release into aquatic systems. To examine the trade-offs of incorporating nano particles (NPs) into sunscreens over the past two...
Resource Type:: Article
Full Text:: , Anjali Mulchandani b, Robert L. Tanguay c, Paul Westerhoff b a Department of Civil and Environmental

ScholarsArchive@OSU

Lipidomics and H₂¹⁸O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

Mono-Substituted Isopropylated Triaryl Phosphate, a Major Component of Firemaster 550, is an AHR Agonist that Exhibits AHR-Independent Cardiotoxicity in Zebrafish

A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants

De novo synthesis of a sunscreen compound in vertebrates

Chronic exposure of killifish to a highly polluted environment desensitizes estrogen–responsive reproductive and biomarker genes

Bisphenol A Exposure During Early Development Induces Sex-Specific Changes in Adult Zebrafish Social Interactions

Toxicity of chlorine to zebrafish embryos

Zebrafish assays as developmental toxicity indicators in the green design of TAML oxidation catalysts

Novel liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos

Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens

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